Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failure

Autor: Hwh van Hees, G.L. Andrade Acuna, Marianne Linkels, Pnr Dekhuijzen, Lma Heunks

Publikováno v: British Journal of Pharmacology. 162:566-573

BACKGROUND AND PURPOSE Diaphragm muscle weakness occurs in patients with heart failure (HF) and is associated with exercise intolerance and increased mortality. Reduced sensitivity of diaphragm fibres to calcium contributes to diaphragm weakness in H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f23c98dbace1a2348a5d7f091ddd47ef
https://doi.org/10.1111/j.1476-5381.2010.01048.x

IMPORTANCE OF TOTAL SERUM IGE FOR IMPROVEMENT IN AIRWAYS HYPERRESPONSIVENESS WITH INHALED CORTICOSTEROIDS IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

Autor: Huib Kerstjens, Jan Schouten, Paul Brand, DFME SCHOONBROOD, PJ STERK, Dirkje Postma, KF KERREBIJN, PH QUANJER, HJ SLUITER, EM POUW, CM ROOS, HM JANSEN, Degooyer, A., TW VANDERMARK, GH KOETER, PM DELONG, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELEERS, BAHA VANDERBRUGGENBOGAARTS, Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, NJ ROBINSON, ER BLEECKER, DA MEYERS

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 151(2), 360-368. AMER THORACIC SOC
University of Groningen

Airways hyperresponsiveness is a hallmark of asthma, and many patients with COPD also demonstrate hyperresponsiveness. Inhaled corticosteroids improve hyperresponsiveness, but the extent of improvement may vary considerably between patients. This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5966eb0064bb634114da993fb69de16a
https://research.rug.nl/en/publications/4688f69a-d6f6-4d56-89e2-af4f79ce087d

A COMPARISON OF FLUTICASONE PROPIONATE, 1-MG DAILY, WITH BECLOMETHASONE DIPROPIONATE, 2-MG DAILY, IN THE TREATMENT OF SEVERE ASTHMA

Autor: NC BARNES, Marone, G., GU DIMARIA, Visser, S., Utama, Andi, SL PAYNE, BAHA VANDERBRUGGENBOGAARTS, KF KERREBIJN, HJ SLUITER, EM POUW, CM ROOS, HM JANSEN, PLP BRAND, Degooyer, A., Huib Kerstjens, DS POSTMA, TW VANDERMARK, GH KOETER, PM DEJONG, PJ STERK, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELERS, Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, NJ ROBINSON, ER BLEECKER, DA MEYERS

Publikováno v: University of Groningen
European Respiratory Journal, 6(6), 877-885. EUROPEAN RESPIRATORY SOC JOURNALS LTD

We wanted to compare the efficacy and safety of fluticasone propionate, a new topically active inhaled corticosteroid, to that of high dose beclomethasone dipropionate, in severe adult asthma. Patients currently receiving between 1.5-2.0 mg.day-1 of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e2f0ffe09afd7424de71ad4cac80c576
https://research.rug.nl/en/publications/6ff05876-6996-4d5b-a620-cdf17c48d502

A COMPARISON OF BRONCHODILATOR THERAPY WITH OR WITHOUT INHALED CORTICOSTEROID-THERAPY FOR OBSTRUCTIVE AIRWAYS DISEASE

Autor: Huib Kerstjens, Paul Brand, MD HUGHES, NJ ROBINSON, Dirkje Postma, HJ SLUITER, ER BLEECKER, PNR DEKHUIJZEN, PM DEJONG, HJJ MENGELERS, SE OVERBEEK, DFME SCHOONBROOD

Publikováno v: University of Groningen
New England Journal of Medicine, 327(20), 1413-1419. MASSACHUSETTS MEDICAL SOC

Background. The morbidity from obstructive airways disease (asthma and chronic obstructive pulmonary disease) is considerable, and the mortality rate is rising in several countries. It has been hypothesized that long-term improvement in prognosis mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eb8ce0832ef2302fff1a76d8040e8f1c
https://research.rug.nl/en/publications/96a93eeb-6239-445d-b6d7-92d2ed641961

Does mixing inhaler devices lead to unchecked inhaler technique errors in patients with COPD? Findings from the cross-sectional observational MISMATCH study.

Autor: Dijk L; General Practitioners Research Institute, Groningen, The Netherlands., Kerkhof M; General Practitioners Research Institute, Groningen, The Netherlands., Driessen M; General Practitioners Research Institute, Groningen, The Netherlands., Gerritsma YH; General Practitioners Research Institute, Groningen, The Netherlands., Bosnic-Anticevich S; Macquarie University, Sydney, New South Wales, Australia.; University of Sydney, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia., Correia-de-Sousa J; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal., Dekhuijzen PNR; Radboud University Nijmegen, Nijmegen, The Netherlands., Leving M; General Practitioners Research Institute, Groningen, The Netherlands., Price DB; Centre of Academic Primary Care, Division of Applied Health Sciences, Univ Aberdeen, Aberdeen, UK.; Observational and Pragmatic Research Institute, Singapore., Tsiligianni I; Department of Social Medicine, Health Planning Unit, Faculty of Medicine, University of Crete, Rethimno, Greece., Usmani O; Airway Disease, National Heart and Lung Institute (NHLI), Imperial College London, London, UK., Kerstjens HAM; Department of Pulmonology, University Medical Center, Groningen, The Netherlands.; University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands., Kocks JWH; General Practitioners Research Institute, Groningen, The Netherlands janwillem@gpri.nl.; Observational and Pragmatic Research Institute, Singapore.; University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands.

Publikováno v: BMJ open respiratory research [BMJ Open Respir Res] 2023 Dec 22; Vol. 10 (1). Date of Electronic Publication: 2023 Dec 22.