Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pnina Raber"'
Publikováno v:
Pain. 146:148-157
Do contrasting neuropathic pain diagnoses share common pathophysiological mechanisms? Selective breeding was used to derive rat lines with a common genetic background but a striking difference in the degree of spontaneous pain behavior expressed in t
Autor:
Benjamin Yakir, Ariel Darvasi, Anne Minert, Marshall Devor, Anne Pisanté, Amit Gilad, Pnina Raber, Jonathan Nissenbaum, Michal Arbilly
Publikováno v:
European Journal of Neuroscience. 26:681-688
Sex and environment may dramatically affect genetic studies, and thus should be carefully considered. Beginning with two inbred mouse strains with contrasting phenotype in the neuroma model of neuropathic pain (autotomy), we established a backcross p
Publikováno v:
Experimental Neurology. 202:200-206
A common strategy for identifying physiological processes responsible for pain is to compare animal strains that show high versus low pain phenotype. However, this approach yields only weak inference because most strains differ from one another at a
Publikováno v:
Pain. 116:294-301
Applying genetic selection pressure to an outbred population of albino rats, we have derived lines that show consistently high versus low pain phenotype in the neuroma model of neuropathic pain. Trait segregation developed rapidly, replicating earlie
Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype
Publikováno v:
Neuroscience. 105:265-275
Selection line rats congenitally high or low for autotomy in the neuroma model of neuropathic pain (HA and LA rats) were found to be correspondingly high and low in a second type of neuropathic pain, the Chung model, which employs an alternative phen
Autor:
Jean-Jacque Vatine, Pnina Raber, David H. Overstreet, Abraham Zangen, R. Zeltser, Galia Carmi, Inna Belfer, Zeʼev Seltzer, Yoram Shir
Publikováno v:
Pain. 90:75-82
In some rat strains, total hindpaw denervation triggers autotomy, a behavior of self mutilation presumably related to neuropathic pain. Partial sciatic ligation (PSL) in rats produces tactile allodynia and heat hyperalgesia but not autotomy. Our aims
Autor:
Svetlana Dolina, Marshall Devor, Pnina Raber, Rafi Zeltser, Inna Belfer, Jean-Jacques Vatine, Ze'ev Seltzer
Publikováno v:
Neuroscience Letters. 279:141-144
Exploratory open field (OF) activity was assessed in seven different mouse strains and selection lines. We counted the number of beam interruptions made by three cagemate mice at a time. This assay tests reactivity to aversive stimuli, anxiety and em
Publikováno v:
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 125:63-74
The effects of selective and non-selective beta-adrenergic agents on cutaneous water evaporation (CWE) were studied in hand-reared rock pigeons (Columba livia). CWE was measured by the vapor diffusive resistance method, using a transient porometer. I
Publikováno v:
NeuroReport. 2:313-316
By selective breeding, lines of rats were derived which consistently expressed high (HA) or low (LA) levels of autotomy following sciatic nerve injury, autotomy being a behavior pattern presumed to reflect the presence of neuropathic paraesthesias an
Autor:
Marshall Devor, Pnina Raber
Publikováno v:
Pain. 42:51-67
Male and female rats underwent transection and ligation of the sciatic and saphenous nerves, and the development of autonomy was monitored. The deafferented animals were then interbred, always selecting males and females that expressed relatively hig