Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor)

Autor: Longati P, Alberto BARDELLI, Ponzetto C, Naldini L, Pm, Comoglio

Publikováno v: Scopus-Elsevier
Europe PubMed Central

The tyrosine kinase encoded by the MET proto-oncogene (p190(MET)) is the receptor for Hepatocyte Growth Factor/Scatter Factor (HGF/SF). Previous work has shown that autophosphorylation of p190(MET) enhances its enzymatic activity and that the major p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::416222f5407a446cc725730080d5ea85
https://pubmed.ncbi.nlm.nih.gov/8302603

Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains

Autor: Alberto BARDELLI, Maina F, Gout I, Mj, Fry, Md, Waterfield, Pm, Comoglio, Ponzetto C

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a polypeptide which induces motility and/or mitogenesis in epithelial cells. The receptor for HGF/SF, p190MET, is a two-chain transmembrane tyrosine kinase encoded by the MET proto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a32bb665c550786d4cc8c729378f8565
http://www.scopus.com/inward/record.url?eid=2-s2.0-0026644455&partnerID=MN8TOARS

cinnamamide analogs as inhibitors of protein tyrosine kinases

Autor: Buzzetti F, Mg, Brasca, Crugnola A, Silvia Fustinoni, Longo A, Penco S, Dalla Zonca P, Pm, Comoglio

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Protein tyrosine kinases (PTK) are important signal transducing enzymes involved in the modulation of normal cellular growth and differentiation and have been associated with the etiology of various human cancers. The development of properly designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f082e45d0be16ade4639b0cc7d258d54
http://www.scopus.com/inward/record.url?eid=2-s2.0-0027170386&partnerID=MN8TOARS

MET Oncogene Enhances Pro-Migratory Functions by Counteracting NMDAR2B Cleavage.

Autor: Gallo S; Department of Oncology, University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, SP142, Km 3.95, 10060 Candiolo, Italy., Vitacolonna A; Department of Oncology, University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, SP142, Km 3.95, 10060 Candiolo, Italy., Comoglio PM; IFOM ETS-The AIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milano, Italy., Crepaldi T; Department of Oncology, University of Turin, Regione Gonzole 10, 10143 Orbassano, Italy.; Candiolo Cancer Institute, FPO-IRCCS, SP142, Km 3.95, 10060 Candiolo, Italy.

Publikováno v: Cells [Cells] 2023 Dec 21; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 21.

Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas.

Autor: De Bacco F; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy; Department of Oncology, University of Turin, 10060 Candiolo, Italy., Orzan F; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Crisafulli G; IFOM ETS - The AIRC Institute of Molecular Oncology, 20139 Milan, Italy., Prelli M; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy; Department of Oncology, University of Turin, 10060 Candiolo, Italy., Isella C; Department of Oncology, University of Turin, 10060 Candiolo, Italy; Laboratory of Oncogenomics, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Casanova E; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Albano R; Core Facilities, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Reato G; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy; Department of Oncology, University of Turin, 10060 Candiolo, Italy., Erriquez J; Core Facilities, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., D'Ambrosio A; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Panero M; Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Dall'Aglio C; Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Casorzo L; Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Cominelli M; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy., Pagani F; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy., Melcarne A; Neurosurgery Unit, Città della Salute e della Scienza University Hospital, 10126 Turin, Italy., Zeppa P; Neurosurgery Unit, Città della Salute e della Scienza University Hospital, 10126 Turin, Italy; Department of Neurosciences, University of Turin, 10126 Turin, Italy., Altieri R; Department of Neurosciences, University of Turin, 10126 Turin, Italy., Morra I; Department of Medical Sciences, University of Turin, 10126 Turin, Italy., Cassoni P; Department of Medical Sciences, University of Turin, 10126 Turin, Italy., Garbossa D; Neurosurgery Unit, Città della Salute e della Scienza University Hospital, 10126 Turin, Italy; Department of Neurosciences, University of Turin, 10126 Turin, Italy., Cassisa A; Laboratory of Oncogenomics, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Bartolini A; Core Facilities, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy., Pellegatta S; Unit of Immunotherapy of Brain Tumors, Fondazione IRCCS Istituto Neurologico C. Besta, 20133 Milan, Italy., Comoglio PM; IFOM ETS - The AIRC Institute of Molecular Oncology, 20139 Milan, Italy., Finocchiaro G; Department of Neurology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy., Poliani PL; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy., Boccaccio C; Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy; Department of Oncology, University of Turin, 10060 Candiolo, Italy. Electronic address: carla.boccaccio@ircc.it.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112816. Date of Electronic Publication: 2023 Jul 27.