Výsledky vyhledávání - "Pm, Blumberg"

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3

Autor: Ey, Chang, Zoltan Szallasi, Acs P, Raizada V, Pc, Wolfe, Fewtrell C, Pm, Blumberg, Rivera J

Publikováno v: Europe PubMed Central

The rat basophilic leukemic (RBL-2H3) cell line was stably transfected with the endogenously expressed Ca2+-dependent protein kinase C-alpha (PKC-alpha) and -betaI and the Ca2+-independent delta and epsilon isoforms to study their functional roles. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a24a48908f93084b703f0359bd42652
https://doi.org/10.4049/jimmunol.159.6.2624

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Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells

Autor: Brodie C, Bogi K, Acs P, Lazarovici P, Gyorgy Petrovics, Wb, Anderson, Pm, Blumberg

Publikováno v: Europe PubMed Central

In this study, we examined the role of specific protein kinase C (PKC) isoforms in the differentiation of PC12 cells in response to nerve growth factor (NGF) and epidermal growth factor (EGF). PC12 cells express PKC-alpha, -beta, -gamma, -delta, -eps

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::efe73d7e917827554032c15b3e633121
https://pubmed.ncbi.nlm.nih.gov/10099832

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Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity

Autor: Bögi K, Ps, Lorenzo, Szállási Z, Acs P, Gs, Wagner, Pm, Blumberg

Publikováno v: Europe PubMed Central

Protein kinase C (PKC) represents the major, high-affinity receptor for the phorbol esters as well as for a series of structurally diverse natural products. The phorbol esters function by binding to the tandem C1a and C1b domains in PKC, leading to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ceb575b9093257ab2194c2064407b3c4
https://pubmed.ncbi.nlm.nih.gov/9537243

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Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression

Autor: Gubina E, Ms, Rinaudo, Zoltan Szallasi, Pm, Blumberg, Ra, Mufson

Publikováno v: Europe PubMed Central

Hematopoietic progenitor cells die by apoptosis after removal of the appropriate colony-stimulating factor (CSF). Recent pharmacologic data have implicated protein kinase C (PKC) in the suppression of apoptosis in interleukin-3 (IL-3) and granulocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f96e977eaf41e27666bfeb5312b440b3
https://pubmed.ncbi.nlm.nih.gov/9446642

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Trifluoperazine modulates [3H]resiniferatoxin binding by human and rat vanilloid (capsaicin) receptors and affects 45Ca uptake by adult rat dorsal root ganglion neurones

Autor: Acs G, Miklós Palkovits, Pm, Blumberg

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Optimum treatment of neuropathic pain includes the use of adjuvant analgesics such as antipsychotic drugs and tricyclic antidepressants. Although the mechanism of their analgesic action is not known, it is possible that such agents act directly on pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6228ee0112cacd194bb8621df5162dca
https://pubmed.ncbi.nlm.nih.gov/7562474

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Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium

Autor: Mf, Denning, Aa, Dlugosz, Ek, Williams, Zoltan Szallasi, Pm, Blumberg, Sh, Yuspa

Publikováno v: Europe PubMed Central

The maturation of epidermal keratinocytes is a tightly regulated, stepwise process which requires protein kinase C (PKC) activation. We investigated the effect of elevated extracellular Ca2+, a potent differentiation signal which increases cellular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::358629d628e743f4b5c1ce662e7854d5
https://pubmed.ncbi.nlm.nih.gov/7756173

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Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes

Autor: Zoltan Szallasi, Kosa K, Cb, Smith, Aa, Dlugosz, Ek, Williams, Sh, Yuspa, Pm, Blumberg

Publikováno v: Europe PubMed Central

12-Deoxyphorbol-13-phenylacetate (dPP) is the prototype for a new class of phorbol derivatives that function as protein kinase C (PKC) activators with potent anti-tumor-promoting activity. To explore the mechanism of action of dPP, we have conducted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b4beaae40a8305cd2f05d93e73921eb
https://pubmed.ncbi.nlm.nih.gov/7870033

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Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat

Autor: Szallasi A, Cristina Goso, Pm, Blumberg, Manzini S

Publikováno v: Europe PubMed Central

Capsazepine was reported to block capsaicin- and resiniferatoxin (RTX)-induced responses both in vivo and in vitro with Schild plots suggesting a competitive mechanism of action. We have used the [3H]RTX binding assay, thought to represent the vanill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a550f0ea44623a2219588c88961b013d
https://pubmed.ncbi.nlm.nih.gov/8246148

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Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin

Autor: Zoltan Szallasi, Krsmanovic L, Pm, Blumberg

Publikováno v: Europe PubMed Central

Prostratin and 12-deoxyphorbol 13-phenylacetate (dPP) form a new class of protein kinase C activators of unique biological activity. Although they bind to and activate protein kinase C, in mouse skin they either fail to induce typical phorbol ester (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ff8847e861d951872c76e3b3e92801dd
https://pubmed.ncbi.nlm.nih.gov/8495413

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