Zobrazeno 1 - 10
of 38 666
pro vyhledávání: '"Pluripotent stem cell"'
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Stem-cell-derived therapy is a promising option for tissue regeneration. Human iPSC-derived progenitors of smooth muscle cells (pSMCs) exhibit limited proliferation and differentiation, which minimizes the risk of tumor formation
Externí odkaz:
https://doaj.org/article/ceb20e69da444bb687a2fcf7722516f2
Publikováno v:
Linchuang shenzangbing zazhi, Vol 24, Iss 8, Pp 687-691 (2024)
Renal toxicity is one of common reasons for a failure of drug research. Thus it is imperative to establish a reliable method of evaluating drug nephrotoxicity. Recently a novel in vitro research model of organoid has attracted growing attention. Orga
Externí odkaz:
https://doaj.org/article/0162ba5082c34e2184746113ea5bdde5
Publikováno v:
Bioactive Materials, Vol 38, Iss , Pp 331-345 (2024)
Cellular reprogramming technologies have been developed with different physicochemical factors to improve the reprogramming efficiencies of induced pluripotent stem cells (iPSCs). Ultrasound is a clinically applied noncontact biophysical factor known
Externí odkaz:
https://doaj.org/article/80b032f3590d43b59ed50a89fc5fb0af
Autor:
Breanna S. Borys, Tiffany Dang, Hannah Worden, Leila Larijani, Jessica M. Corpuz, Brett D. Abraham, Emilie J. Gysel, Julia Malinovska, Roman Krawetz, Tamas Revay, Bob Argiropoulos, Derrick E. Rancourt, Michael S. Kallos, Sunghoon Jung
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background While pluripotent stem cell (PSC) therapies move toward clinical and commercial applications at a rapid rate, manufacturing reproducibility and robustness are notable bottlenecks in regulatory approval. Therapeutic applications of
Externí odkaz:
https://doaj.org/article/2db8d01dfcf348088a43dc9d70f85a86
Autor:
Zhonghao Li, Wei Wu, Qiushi Li, Xin Heng, Wei Zhang, Yinghong Zhu, Lin Chen, Ziqi Chen, Mengcheng Shen, Ning Ma, Qingzhong Xiao, Yi Yan
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background B-cell CLL/lymphoma 6 member B (BCL6B) operates as a sequence-specific transcriptional repressor within the nucleus, playing crucial roles in various biological functions, including tumor suppression, immune response, stem cell se
Externí odkaz:
https://doaj.org/article/a2178cb2bac14aad8ab9dab35282fc0c
Autor:
Jie Liu, Guang Kong, Chenlin Lu, Juan Wang, Wenbo Li, Zhengming Lv, Jian Tong, Yuan Liu, Wu Xiong, Haijun Li, Jin Fan
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Following spinal cord injury (SCI), the inflammatory storm initiated by microglia/macrophages poses a significant impediment to the recovery process. Exosomes play a crucial role in the transport of miRNAs, facilitating essential
Externí odkaz:
https://doaj.org/article/3ee5e65d0a4c47f7982003bcf3bbe743
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Stem cell-derived therapies hold the potential for treatment of regenerative clinical indications. Static culture has a limited ability to scale up thus restricting its use. Suspension culturing can be used to produce target cells
Externí odkaz:
https://doaj.org/article/85bd865afc824aaeb64b634a62a22d86
Autor:
Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Lifu Sun, Akima Harada, Ying Hua, Nagako Sougawa, Akiko Tabata, Li Liu, Shigeru Miyagawa
Publikováno v:
Bioactive Materials, Vol 37, Iss , Pp 533-548 (2024)
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been widely used in therapy of ischemic heart disease. However, there are still remaining issues that limit the therapeutic efficacy, such as immune rejection and low retenti
Externí odkaz:
https://doaj.org/article/fb2d290dc6924a5588fb4b8e5ff48308
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 22-31 (2024)
Symmetry breaking leading to axis formation and spatial patterning is crucial for achieving more accurate recapitulation of human development in organoids. While these processes can occur spontaneously by self-organizing capabilities of pluripotent s
Externí odkaz:
https://doaj.org/article/0dc79d0f5e9f4480953523c774fc7644
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 749-759 (2024)
Introduction: Neural crest cells (NCCs) are cell populations that originate during the formation of neural crest in developmental stages. They are characterized by their multipotency, self-renewal and migration potential. Given their ability to diffe
Externí odkaz:
https://doaj.org/article/532571a6926e45ea9b4488c6b4d6fa41