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Berenil [1,3-Bis(4'-amidinophenyl)triazene] Binding to DNA Duplexes and to a RNA Duplex: Evidence for Both Intercalative and Minor Groove Binding Properties

Autor: Daniel S. Pilch, Xiaoyan Liu, M. A. Kirolos, Kenneth J. Breslauer, Plum Ge

Publikováno v: Biochemistry. 34:9962-9976

Berenil is an antitrypanosomal agent that binds to nucleic acid duplexes. The generally accepted mode of berenil binding is via complexation into the minor groove of AT-rich domains of DNA double helices. We find that berenil can bind to RNA as well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb85541f6a209ae884473c956cce1c31
https://doi.org/10.1021/bi00031a019

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Influence of Drug Binding on DNA Hydration: Acoustic and Densimetric Characterizations of Netropsin Binding to the Poly(dAdT).cntdot.Poly(dAdT) and Poly(dA).cntdot.Poly(dT) Duplexes and the Poly(dT).cntdot.Poly(dA).cntdot.Poly(dT) Triplex at 25 .degree.C

Autor: Tigran V. Chalikian, Armen Sarvazyan, Plum Ge, Kenneth J. Breslauer

Publikováno v: Biochemistry. 33:8629-8640

We use high-precision acoustic and densimetric techniques to determine, at 25 degrees C, the changes in volume, delta V, and adiabatic compressibility, delta Ks, that accompany the binding of netropsin to the poly(dAdT).poly(dAdT) and poly(dA).poly(d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac1c7767369b0622d1884b61c89c773f
https://doi.org/10.1021/bi00195a003

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Influence of Base Composition, Base Sequence, and Duplex Structure on DNA Hydration: Apparent Molar Volumes and Apparent Molar Adiabatic Compressibilities of Synthetic and Natural DNA Duplexes at 25.degree.C

Autor: Kenneth J. Breslauer, Tigran V. Chalikian, Plum Ge, Armen Sarvazyan

Publikováno v: Biochemistry. 33:2394-2401

Using high-precision densitometric and ultrasonic measurements, we have determined, at 25 degrees C, the apparent molar volumes, phi V, and the apparent molar compressibilities, phi KS, of five natural and three synthetic B-form DNA duplexes with var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac70fde90b4efb9e30aa75e7f4d6a93
https://doi.org/10.1021/bi00175a007

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Influence of an exocyclic guanine adduct on the thermal stability, conformation, and melting thermodynamics of a DNA duplex

Autor: Francis Johnson, Arthur P. Grollman, Kenneth J. Breslauer, Plum Ge

Publikováno v: Biochemistry. 31:12096-12102

As part of an overall program to characterize the impact of mutagenic lesions on the physiochemical properties of DNA, we report here the results of a comparative spectroscopic study on pairs of DNA duplexes both with and without an exocyclic guanine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aab0e0e313573baf017ba96ec4f8b1c
https://doi.org/10.1021/bi00163a019

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Conformational energetics of stable and metastable states formed by DNA triplet repeat oligonucleotides: Implications for triplet expansion diseases

Autor: N. Makube, Horst H. Klump, Jens Völker, Plum Ge, Kenneth J. Breslauer

We have embedded the hexameric triplet repeats (CAG) 6 and (CTG) 6 between two (GC) 3 domains to produce two 30-mer hairpins with the sequences d[(GC) 3 (CAG) 6 (GC) 3 ] and d[(GC) 3 (CTG) 6 (GC) 3 ]. This construct reduces the conformational space a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293ba9d7ba7cb8018d1767c7e7c6df90
https://europepmc.org/articles/PMC137482/

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Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex

Autor: Plum Ge, Arthur P. Grollman, Francis Johnson, Kenneth J. Breslauer

Publikováno v: Biochemistry. 34(49)

As part of an overall program to characterize the impact of mutagenic lesions on the physiochemical properties of DNA, we report here the results of a comparative spectroscopic and calorimetric study on a family of DNA duplexes both with and without

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bcd275732f498706197ae20fe65f65
https://pubmed.ncbi.nlm.nih.gov/8519772

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Thermodynamics of an intramolecular DNA triple helix: a calorimetric and spectroscopic study of the pH and salt dependence of thermally induced structural transitions

Autor: Kenneth J. Breslauer, Plum Ge

Publikováno v: Journal of molecular biology. 248(3)

We have characterized thermodynamically the melting transitions of a DNA 31-mer oligonucleotide (5'-GAAGAGGTTTTTCCTCTTCTTTTTCTTCTCC-3') which is designed to fold into an intramolecular triple helix. The first 19 residues fold back on themselves to fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007bbcc066ea50d03d973d40ac19b118
https://pubmed.ncbi.nlm.nih.gov/7752233

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Thermodynamic characterization of the stability and the melting behavior of a DNA triplex: a spectroscopic and calorimetric study

Autor: S. F. Singleton, Peter B. Dervan, Plum Ge, Kenneth J. Breslauer, Young-Whan Park

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 87(23)

We report a complete thermodynamic characterization of the stability and the melting behavior of an oligomeric DNA triplex. The triplex chosen for study forms by way of major-groove Hoogsteen association of an all-pyrimidine 15-mer single strand (ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197879928b5c9b74d1d15de6a0a6642c
https://pubmed.ncbi.nlm.nih.gov/2251285

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