Zobrazeno 1 - 10
of 736
pro vyhledávání: '"Plpro"'
Publikováno v:
Journal of Biosafety and Biosecurity, Vol 6, Iss 3, Pp 211-221 (2024)
This study aims to investigate the potential impact of inhibitors targeting the papain-like protease (PLpro) of SARS-CoV-2 on viral replication and the host immune response. A mathematical model was developed to simulate the interaction among suscept
Externí odkaz:
https://doaj.org/article/25970283289c4f28af06fe1894bad65f
Publikováno v:
Future Pharmacology, Vol 4, Iss 3, Pp 510-540 (2024)
(1) Background: The SARS-CoV-2 papain-like protease (PLpro) remains an underexplored antiviral target so far. The reduced efficacy of approved treatments against novel variants highlights the importance of developing new agents. This review aims to p
Externí odkaz:
https://doaj.org/article/0cff1e79a88e4c77ac02961e6733dc53
Autor:
Mei Li, Zhu-Chun Bei, Yongtian Yuan, Baogang Wang, Dongna Zhang, Likun Xu, Liangliang Zhao, Qin Xu, Yabin Song
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Papain-like protease (PLpro) is an attractive anti-coronavirus target. The development of PLpro inhibitors, however, is hampered by the limitations of the existing PLpro assay and the scarcity of validated active compounds. We developed a novel in-ce
Externí odkaz:
https://doaj.org/article/5a01b9e861734741bbb82b9fba6c65f7
Autor:
Ivana Nemčovičová, Katarína Lopušná, Iveta Štibrániová, Fabio Benedetti, Federico Berti, Fulvia Felluga, Sara Drioli, Mattia Vidali, Jaroslav Katrlík, Lucia Pažitná, Alena Holazová, Jana Blahutová, Simona Lenhartová, Monika Sláviková, Boris Klempa, Miroslav Ondrejovič, Daniela Chmelová, Barbora Legerská, Stanislav Miertuš, Mária Klacsová, Daniela Uhríková, Lukáš Kerti, Vladimír Frecer
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractThe viral genome of the SARS-CoV-2 coronavirus, the aetiologic agent of COVID-19, encodes structural, non-structural, and accessory proteins. Most of these components undergo rapid genetic variations, though to a lesser extent the essential v
Externí odkaz:
https://doaj.org/article/1ab0d8cfa120432f8905bf2f4c7f5d07
Autor:
B.Sc. Sara Protić, M.Sc. Milica Crnoglavac Popović, M.Sc. Nevena Kaličanin, Dr. Olivera Prodanović, Dr. Milan Senćanski, Dr. Jelena Milićević, Dr. Kristina Stevanović, Dr. Vladimir Perović, Dr. Slobodan Paessler, Dr. Radivoje Prodanović, Dr. Sanja Glišić
Publikováno v:
ChemistryOpen, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract The emergence of drug‐resistant viruses and novel strains necessitates the rapid development of novel antiviral therapies. This need was particularly demanding during the COVID‐19 pandemic. While de novo drug development is a time‐cons
Externí odkaz:
https://doaj.org/article/9fdc7793792c4bc5a3bb2984aed9eefb
Autor:
Miao Zheng, Bo Feng, Yumin Zhang, Xin Liu, Na Zhao, Hui Liu, Zichao Xu, Xinheng He, Zhiyan Qu, Shizhao Chen, Zhidong Jiang, Xi Cheng, Hong Liu, Yi Zang, Linxiang Zhao, Jie Zheng, Leike Zhang, Jia Li, Yu Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3286-3290 (2024)
Externí odkaz:
https://doaj.org/article/0507dae3bcfe403cb289ec049acee92e
Publikováno v:
Plants, Vol 13, Iss 23, p 3319 (2024)
Despite the now infamous coronavirus disease outbreaks caused by severe acute respiratory syndrome coronavirus (SARS-CoV), this virus continues to be a threat to the global population. Although a huge research effort has targeted SARS-CoV, no report
Externí odkaz:
https://doaj.org/article/10bb4796481646cea1a720e15b210235
Autor:
Wonjin Bang, Jaehyun Kim, Kanghun Seo, Jihyun Lee, Ji Ho Han, Daegyu Park, Jae Hwan Cho, Donghyuk Shin, Kyun-Hwan Kim, Moon Jung Song, Jin-Hyun Ahn
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Protein modification by the ubiquitin-like protein ISG15 (ISGylation) plays a crucial role in the immunological defense against viral infection. During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, innate immune signaling pr
Externí odkaz:
https://doaj.org/article/68c609825bce41ff81028859d3786b9d
Autor:
Luana G. de Souza, Eduarda A. Penna, Alice S. Rosa, Juliana C. da Silva, Edgar Schaeffer, Juliana V. Guimarães, Dennis M. de Paiva, Vinicius C. de Souza, Vivian Neuza S. Ferreira, Daniel D. C. Souza, Sylvia Roxo, Giovanna B. Conceição, Larissa E. C. Constant, Giovanna B. Frenzel, Matheus J. N. Landim, Maria Luiza P. Baltazar, Celimar Cinézia Silva, Ana Laura Macedo Brand, Julia Santos Nunes, Tadeu L. Montagnoli, Gisele Zapata-Sudo, Marina Amaral Alves, Diego Allonso, Priscila V. Z. Capriles Goliatt, Milene D. Miranda, Alcides J. M. da Silva
Publikováno v:
Viruses, Vol 16, Iss 11, p 1768 (2024)
Endemic and pandemic viruses represent significant public health challenges, leading to substantial morbidity and mortality over time. The COVID-19 pandemic has underscored the urgent need for the development and discovery of new, potent antiviral ag
Externí odkaz:
https://doaj.org/article/1585db47579f45d4b4267e555a109e42
Autor:
Jiahao Fan, Pengyuan Xi, Huimao Liu, Xu Song, Xinghong Zhao, Xun Zhou, Yuanfeng Zou, Yuping Fu, Lixia Li, Renyong Jia, Zhongqiong Yin
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Myricetin, a natural flavonoid found in various foods, was investigated for its antiviral effect against transmissible gastroenteritis virus (TGEV). This α-coronavirus causes significant economic losses in the global swine industry. The study focuse
Externí odkaz:
https://doaj.org/article/c6f3755b3e024d1896d4a36714604c22