Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.

Autor: Liu L; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Malagu K; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Haughan AF; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Khetarpal V; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Stott AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Esmieu W; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Vater HD; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Webster SJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Van de Poël AJ; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clissold C; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Cosgrove B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Sutton B; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Spencer JA; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Breccia P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Gancia E; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Bonomo S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Ladduwahetty T; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Lazari O; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Patel H; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Atton HC; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Clifton S; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mota DM; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Magnani D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., O'Neill A; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Stebbeds M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Macabuag N; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Todd D; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Herva ME; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Mitchell P; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Visser M; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Compte Sancerni S; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Grand Moursel L; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., da Silva M; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Kritikou E; Charles River, Darwinweg 24, 2333 CR Leiden, The Netherlands., Heikkinen TT; Charles River, Microkatu 1, Kuopio 70210 Finland., Bolkvadze T; Charles River, Microkatu 1, Kuopio 70210 Finland., Fodale V; IRBM S.p.A., Pomezia, Roma 00071, Italy., Spadafora D; IRBM S.p.A., Pomezia, Roma 00071, Italy., Daldin M; IRBM S.p.A., Pomezia, Roma 00071, Italy., Bresciani A; IRBM S.p.A., Pomezia, Roma 00071, Italy., Mangette JE; Curia Global, Inc., Buffalo, New York 14203, United States., Doherty EM; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Lee MR; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Herbst T; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Monteagudo E; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Macdonald D; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Plotnikov NV; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Chambers M; Discovery from Charles River, Charles River, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., McAllister G; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Muňoz-Sanjuan I; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States., Dominguez C; CHDI Management/CHDI Foundation, 6080 Center Drive, Los Angeles, California 90045, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 13205-13246. Date of Electronic Publication: 2023 Sep 15.

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.

Autor: Haile PA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Casillas LN; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Bury MJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Mehlmann JF; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Singhaus R Jr; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Charnley AK; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Hughes TV; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., DeMartino MP; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Wang GZ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Romano JJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Dong X; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Plotnikov NV; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Lakdawala AS; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Convery MA; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom., Votta BJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Lipshutz DB; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Desai BM; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Swift B; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Capriotti CA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Berger SB; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Mahajan MK; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Reilly MA; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Rivera EJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Sun HH; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Nagilla R; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., LePage C; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Ouellette MT; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Totoritis RD; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Donovan BT; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Brown BS; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Chaudhary KW; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Gough PJ; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Bertin J; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States., Marquis RW; GlaxoSmithKline, Collegeville Road, Collegeville, Pennsylvania 19426, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Sep 26; Vol. 9 (10), pp. 1039-1044. Date of Electronic Publication: 2018 Sep 26 (Print Publication: 2018).

Quantifying the Risks of Asparagine Deamidation and Aspartate Isomerization in Biopharmaceuticals by Computing Reaction Free-Energy Surfaces.

Autor: Plotnikov NV; Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. , 700 Chesterfield Pkwy West, Chesterfield, Missouri 63017, United States., Singh SK; Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. , 700 Chesterfield Pkwy West, Chesterfield, Missouri 63017, United States., Rouse JC; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. , 1 Burtt Road, Andover, Massachusetts 01810, United States., Kumar S; Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc. , 700 Chesterfield Pkwy West, Chesterfield, Missouri 63017, United States.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2017 Feb 02; Vol. 121 (4), pp. 719-730. Date of Electronic Publication: 2017 Jan 19.

Quantitative exploration of the molecular origin of the activation of GTPase.

Autor: B RP; Department of Chemistry, University of Southern California, Los Angeles, CA 90089., Plotnikov NV, Lameira J, Warshel A

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Dec 17; Vol. 110 (51), pp. 20509-14. Date of Electronic Publication: 2013 Nov 26.

Addressing open questions about phosphate hydrolysis pathways by careful free energy mapping.

Autor: Prasad BR; Department of Chemistry, University of Southern California, SGM 418, 3620 McClintock Avenue, Los Angeles, California 90089, United States., Plotnikov NV, Warshel A

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2013 Jan 10; Vol. 117 (1), pp. 153-63. Date of Electronic Publication: 2012 Dec 28.