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Disease concepts and treatment by tribal healers of an Amazonian forest culture

Autor: Plotkin Mark J, Uremaru Amasina, Uiterloo Melvin, Herndon Christopher N, Emanuels-Smith Gwendolyn, Jitan Jeetendra

Publikováno v: Journal of Ethnobiology and Ethnomedicine, Vol 5, Iss 1, p 27 (2009)

Abstract Background The extensive medicinal plant knowledge of Amazonian tribal peoples is widely recognized in the scientific literature and celebrated in popular lore. Despite this broad interest, the ethnomedical systems and knowledge of disease w

Externí odkaz: https://doaj.org/article/4fc51498cc3244d1bfcbd85d87af1048

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Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.

Autor: Plotkin MA; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Labroli M; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schubert J; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Shaw A; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schlegel KS; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Berger R; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cooke AJ; Medicinal Chemistry, Exscientia, 53 State Street, Boston, Massachusetts 02109, United States., Hayes RP; Protein and Structural Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Armacost KA; Computational Sciences, GlaxoSmithKline, Collegeville Pennsylvania 19426, United States., Kinek K; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Krosky P; In Vitro Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; In Vitro Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Meng S; In Vitro Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., DiNunzio E; Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Murray EM; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Agrawal S; Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Madeira M; Discovery Pharmaceutical Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Flattery A; In Vivo Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Yao H; Discovery Pharmaceutical Sciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Rose WA 2nd; In Vivo Pharmacology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cox C; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Tellers DM; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., McKenna PM; Discovery Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Raheem I; Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 09; Vol. 15 (8), pp. 1232-1241. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.

Autor: Beshore DC; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Adam GC; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Barnard RJO; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Burlein C; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Gallicchio SN; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Holloway MK; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Krosky D; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Lemaire W; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Myers RW; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Patel S; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Plotkin MA; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Powell DA; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Rada V; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Cox CD; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Coleman PJ; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Klein DJ; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Wolkenberg SE; MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 07; Vol. 12 (4), pp. 540-547. Date of Electronic Publication: 2021 Mar 07 (Print Publication: 2021).

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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.

Autor: Liu W; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Hussain Z; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Zang Y; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Sweis RF; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Romero FA; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Finke PE; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Moningka R; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Bao J; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Plotkin MA; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Shang J; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Dingley KH; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Salituro G; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Murphy BA; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Howard AD; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Ujjainwalla F; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Wood HB; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Duffy JL; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Oct 05; Vol. 9 (11), pp. 1088-1093. Date of Electronic Publication: 2018 Oct 05 (Print Publication: 2018).

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Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].

Autor: Lombardo M; Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address: matthew_lombardo@merck.com., Bender K; Merck & Co., Inc., Kenilworth, NJ, USA., London C; Merck & Co., Inc., Kenilworth, NJ, USA., Plotkin MA; Merck & Co., Inc., Kenilworth, NJ, USA., Kirkland M; Merck & Co., Inc., Kenilworth, NJ, USA., Mane J; Merck & Co., Inc., Kenilworth, NJ, USA., Pachanski M; Merck & Co., Inc., Kenilworth, NJ, USA., Geissler W; Merck & Co., Inc., Kenilworth, NJ, USA., Cummings J; Merck & Co., Inc., Kenilworth, NJ, USA., Habulihaz B; Merck & Co., Inc., Kenilworth, NJ, USA., Akiyama TE; Merck & Co., Inc., Kenilworth, NJ, USA., Di Salvo J; Merck & Co., Inc., Kenilworth, NJ, USA., Madeira M; Merck & Co., Inc., Kenilworth, NJ, USA., Pols J; Merck & Co., Inc., Kenilworth, NJ, USA., Powles MA; Merck & Co., Inc., Kenilworth, NJ, USA., Finley MF; Merck & Co., Inc., Kenilworth, NJ, USA., Johnson E; Merck & Co., Inc., Kenilworth, NJ, USA., Roussel T; Merck & Co., Inc., Kenilworth, NJ, USA., Uebele VN; Merck & Co., Inc., Kenilworth, NJ, USA., Crespo A; Merck & Co., Inc., Kenilworth, NJ, USA., Leung D; Merck & Co., Inc., Kenilworth, NJ, USA., Alleyne C; Merck & Co., Inc., Kenilworth, NJ, USA., Trusca D; Merck & Co., Inc., Kenilworth, NJ, USA., Lei Y; Merck & Co., Inc., Kenilworth, NJ, USA., Howard AD; Merck & Co., Inc., Kenilworth, NJ, USA., Ujjainwalla F; Merck & Co., Inc., Kenilworth, NJ, USA., Tata JR; Merck & Co., Inc., Kenilworth, NJ, USA., Sinz CJ; Merck & Co., Inc., Kenilworth, NJ, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Mar 01; Vol. 27 (5), pp. 1333. Date of Electronic Publication: 2017 Feb 04.

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