Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ploi Yibmantasiri"'
Autor:
Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto, Rik J. Lories
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that in
Externí odkaz:
https://doaj.org/article/04bc89636776490eb64098d886437b56
Autor:
Frédéric Cailotto, Silvia Monteagudo, Peter Carmeliet, Carolina Aznar-Lopez, Rik Lories, Laura-An Guns, F.M. Cornelis, Ploi Yibmantasiri
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, pp.15889. ⟨10.1038/ncomms15889⟩
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, Nature Publishing Group, 2017, 8, pp.15889. ⟨10.1038/ncomms15889⟩
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9ca598f0864a75baf158d66c0e007
https://lirias.kuleuven.be/handle/123456789/592476
https://lirias.kuleuven.be/handle/123456789/592476
Publikováno v:
Mol. BioSyst.. 10:128-137
The pleiotropic drug response (PDR) or multidrug resistance (MDR) are cellular defence mechanisms present in all species to deal with potential toxicity from environmental small molecule toxins or bioactives. The rapid induction of MDR by xenobiotics
Autor:
Paul H. Atkinson, Greta Moraes, Bede P. Busby, Rosemary W. Heathcott, Stephan Andreas Angermayr, David S. Bellows, Dora C. Leahy, James H. Matthews, Kristina Boeger, Alice G. Sorgo, Peter T. Northcote, Jacqueline M. Barber, Ploi Yibmantasiri
Publikováno v:
Molecular bioSystems. 8(3)
Neothyonidioside is a triterpene glycoside (TG) isolated from the sea cucumber, Australostichopus mollis, that is potently cytotoxic to S. cerevisiae, but does not permeabilize cellular membranes. We mutagenized S. cerevisiae and isolated a neothioni