In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

Autor: Sweeney AM; Center for Translational Neuromedicine, University of Rochester Medical Center., Plá V; Center for Translational Neuromedicine, University of Rochester Medical Center., Du T; Center for Translational Neuromedicine, University of Rochester Medical Center., Liu G; Center for Translational Neuromedicine, University of Rochester Medical Center., Sun Q; Center for Translational Neuromedicine, University of Rochester Medical Center., Peng S; Center for Translational Neuromedicine, University of Rochester Medical Center., Plog BA; Center for Translational Neuromedicine, University of Rochester Medical Center., Kress BT; Center for Translational Neuromedicine, University of Rochester Medical Center., Wang X; Center for Translational Neuromedicine, University of Rochester Medical Center., Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center; Humberto_Mestre@urmc.rochester.edu., Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center; Center for Translational Neuromedicine, University of Copenhagen; maiken_nedergaard@urmc.rochester.edu.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2019 Jul 29 (149). Date of Electronic Publication: 2019 Jul 29.

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Autor: Mestre H; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Hablitz LM; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Xavier AL; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark., Feng W; Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China., Zou W; Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China., Pu T; Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China., Monai H; RIKEN Center for Brain Science, Wako, Japan.; Ochanomizu University, Tokyo, Japan., Murlidharan G; Gene Therapy Center, The University of North Carolina, Chapel Hill, United States., Castellanos Rivera RM; Gene Therapy Center, The University of North Carolina, Chapel Hill, United States., Simon MJ; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, United States., Pike MM; Advanced Imaging Research Center, Oregon Health and Science University, Portland, United States., Plá V; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Du T; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Kress BT; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Wang X; RIKEN Center for Brain Science, Wako, Japan., Plog BA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States., Thrane AS; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway., Lundgaard I; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Abe Y; Department of Pharmacology,School of Medicine, Keio University, Tokyo, Japan., Yasui M; Department of Pharmacology,School of Medicine, Keio University, Tokyo, Japan., Thomas JH; Department of Mechanical Engineering, University of Rochester, Rochester, United States.; Department of Physics and Astronomy, University of Rochester, Rochester, United States., Xiao M; Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China., Hirase H; RIKEN Center for Brain Science, Wako, Japan.; Brain and Body System Science Institute, Saitama University, Saitama, Japan., Asokan A; Gene Therapy Center, The University of North Carolina, Chapel Hill, United States.; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, North Carolina, United States.; Department of Surgery, Duke University School of Medicine, Durham, United States., Iliff JJ; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, United States.; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, United States., Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, United States.; Center for Translational Neuromedicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: ELife [Elife] 2018 Dec 18; Vol. 7. Date of Electronic Publication: 2018 Dec 18.

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Autor: Plog BA; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Pathology, and., Mestre H; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA., Olveda GE; Center for Translational Neuromedicine, Department of Neurosurgery., Sweeney AM; Center for Translational Neuromedicine, Department of Neurosurgery., Kenney HM; Center for Translational Neuromedicine, Department of Neurosurgery., Cove A; Center for Translational Neuromedicine, Department of Neurosurgery., Dholakia KY; Center for Translational Neuromedicine, Department of Neurosurgery., Tithof J; Department of Mechanical Engineering and., Nevins TD; Department of Physics and Astronomy, University of Rochester, Rochester, New York, USA., Lundgaard I; Center for Translational Neuromedicine, Department of Neurosurgery., Du T; Center for Translational Neuromedicine, Department of Neurosurgery.; Laboratory of Metabolic Brain Diseases, Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China., Kelley DH; Department of Mechanical Engineering and., Nedergaard M; Center for Translational Neuromedicine, Department of Neurosurgery.; Department of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA.

Publikováno v: JCI insight [JCI Insight] 2018 Oct 18; Vol. 3 (20). Date of Electronic Publication: 2018 Oct 18.

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

Autor: Louveau A; Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia, USA., Plog BA; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA., Antila S; Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Alitalo K; Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Nedergaard M; Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York, USA.; Center of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kipnis J; Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2017 Sep 01; Vol. 127 (9), pp. 3210-3219. Date of Electronic Publication: 2017 Sep 01.

Why have we not yet developed a simple blood test for TBI?

Autor: Plog BA; Department of Neurosurgery, Center for Translational Neuromedicine, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Ave, Box 645, Rochester, NY 14642, USA., Nedergaard M

Publikováno v: Expert review of neurotherapeutics [Expert Rev Neurother] 2015 May; Vol. 15 (5), pp. 465-8. Date of Electronic Publication: 2015 Mar 30.