Mesothelial cell HIF1α expression is metabolically downregulated by metformin to prevent oncogenic tumor-stromal crosstalk

Autor: Hart, P.C., Kenny, H.A., Grassl, N., Watters, K.M., Litchfield, L.M., Coscia, F., Blaženović, I., Ploetzky, L., Fiehn, O., Mann, M., Lengyel, E., Romero, I.L.

The tumor microenvironment (TME) plays a pivotal role in cancer progression, and, in ovarian cancer (OvCa), the primary TME is the omentum. Here, we show that the diabetes drug metformin alters mesothelial cells in the omental microenvironment. Metfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=mdc______med::d21b9b7249465edc652007f3c3c58c65
http://edoc.mdc-berlin.de/20269/1/20269oa.pdf

Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.

Autor: Hart PC; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA., Kenny HA; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA., Grassl N; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Watters KM; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA., Litchfield LM; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA., Coscia F; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Blaženović I; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA., Ploetzky L; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA., Fiehn O; West Coast Metabolomics Center, University of California, Davis Genome Center, Davis, CA, USA., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany., Lengyel E; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: elengyel@uchicago.edu., Romero IL; Department of Obstetrics and Gynecology/Section of Gynecologic Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: iromero@bsd.uchicago.edu.

Publikováno v: Cell reports [Cell Rep] 2019 Dec 17; Vol. 29 (12), pp. 4086-4098.e6.