SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).

Autor: Curtin ML; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com., Heyman HR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Clark RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sorensen BK; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Doherty GA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Hansen TM; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Frey RR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sarris KA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Aguirre AL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Shrestha A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tu N; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Woller K; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Pliushchev MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sweis RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng M; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Wilsbacher JL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Kovar PJ; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Guo J; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Longenecker KL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Raich D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Korepanova AV; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Soni NB; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Algire MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Richardson PL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Marin VL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Badagnani I; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Vasudevan A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Buchanan FG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Maag D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Chiang GG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tse C; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Michaelides MR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 01; Vol. 27 (15), pp. 3317-3325. Date of Electronic Publication: 2017 Jun 14.

Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

Autor: Rohde JJ; Metabolic Disease Research, Abbott Laboratories, Department R4CB, Building AP52, Abbott Park, Illinois 60064-3500, USA. jeffrey.j.rhode@abbott.com, Pliushchev MA, Sorensen BK, Wodka D, Shuai Q, Wang J, Fung S, Monzon KM, Chiou WJ, Pan L, Deng X, Chovan LE, Ramaiya A, Mullally M, Henry RF, Stolarik DF, Imade HM, Marsh KC, Beno DW, Fey TA, Droz BA, Brune ME, Camp HS, Sham HL, Frevert EU, Jacobson PB, Link JT

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2007 Jan 11; Vol. 50 (1), pp. 149-64.