TRKB interaction with PSD95 is associated with latency of fluoxetine and 2R,6R‐hydroxynorketamine

Autor: Senem Merve Fred, Rafael Moliner, Hanna Antila, Karl‐Alexander Engelhardt, Oliver M. Schlüter, Plinio C. Casarotto, Eero Castrén

Publikováno v: European Journal of Neuroscience. 57:1215-1224

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5306822f974d40c60b7fbe00d37a28f3
https://doi.org/10.1111/ejn.15952

Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model

Autor: Deidiane Elisa Ribeiro, Plinio C. Casarotto, Laura Staquini, Maria Augusta Pinto e Silva, Caroline Biojone, Gregers Wegener, Samia Joca

Publikováno v: PeerJ, Vol 7, p e7834 (2019)

Purinergic receptors, especially P2RX, are associated to the severity of symptoms in patients suffering from depressive and bipolar disorders, and genetic deletion or pharmacological blockade of P2RX7 induces antidepressant-like effect in preclinical

Externí odkaz: https://doaj.org/article/ede8cc83cf1b4a0d9876636d99794842

nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity

Autor: Caroline Biojone, Plinio C Casarotto, Cecilia Cannarozzo, Senem Merve Fred, Rosa Herrera-Rodríguez, Angelina Lesnikova, Mikko Voipio, Eero Castrén

Publikováno v: Biojone, C, C Casarotto, P, Cannarozzo, C, Fred, S M, Herrera-Rodríguez, R, Lesnikova, A, Voipio, M & Castrén, E 2023, ' nNOS-induced tyrosine nitration of TRKB impairs BDNF signaling and restrains neuronal plasticity ', Progress in Neurobiology, vol. 222, 102413 . https://doi.org/10.1016/j.pneurobio.2023.102413

Nitric oxide (NO) has been long recognized as an important modulator of neural plasticity, but characterization of the molecular mechanisms involved -specially the guanylyl cyclase-independent ones -has been challenging. There is evidence that NO cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ffad7c44828901dce82f55878fc2a2
https://pure.au.dk/portal/da/publications/nnosinduced-tyrosine-nitration-of-trkb-impairs-bdnf-signaling-and-restrains-neuronal-plasticity(f37fdea9-2786-43b0-a72b-59b9b9f932c4).html

Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania

Autor: Plinio C. Casarotto, Caroline Biojone, Karina Montezuma, Fernando Q. Cunha, Samia R.L. Joca, Eero Castren, Francisco S. Guimaraes

Publikováno v: PeerJ, Vol 6, p e4635 (2018)

Background Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but

Externí odkaz: https://doaj.org/article/d790a144c3af4c928d866732a1511edb

Chondroitinase and Antidepressants Promote Plasticity by Releasing TRKB from Dephosphorylating Control of PTPσ in Parvalbumin Neurons

Autor: Hanna Antila, Plinio C. Casarotto, Eero Castrén, Frederike Winkel, Anna Steinzeig, Mikko Voipio, Caroline Biojone, Angelina Lesnikova, Senem Merve Fred, Juzoh Umemori

Publikováno v: The Journal of Neuroscience
BioRxiv
bioRxiv

Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulfate proteoglycans (CSPGs), which preferentially encase parvalbumin-containing (PV+) interneurons. PNNs restrict cortical network plasticity but the molecular mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22730c7be739c0adcc5e771235008558
http://europepmc.org/articles/PMC7880295