Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Plinio Perrone"'
Autor:
Isabel Najera, G Luoni, Klaus Klumpp, David Bernard Smith, Sophie Le Pogam, Sinead Mulready, Sonal Rajyaguru, Christopher McGuigan, Mary Rose Kelleher, Plinio Perrone, Felice Daverio, Joseph A. Martin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4250-4254
We report the design, synthesis and evaluation of a family of ca 50 phosphoramidate ProTides of the potent anti-HCV compound 4'-azidocytidine (R1479), with variation on the ester, amino acid and aryl moiety of the ProTide. Sub-muM inhibitors of HCV e
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4316-4320
Beta-2'-C-methyl purines (1, 2) are known inhibitors of hepatitis C virus (HCV). We herein report the synthesis, biological and enzymatic evaluation of their 5'-phosphoramidate ProTides. Described herein are seven l-alanine phosphoramidate derivative
Autor:
Alessia Amore, Marcello Allegretti, Alberto Dolce, Andrea Aramini, Manolo R. Sablone, Gianluca Bianchini, Plinio Perrone, Michela Fani
Publikováno v:
Tetrahedron. 65:2015-2021
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key
Autor:
Gianluca Bianchini, Alessia Amore, Manolo R. Sablone, Alberto Dolce, Plinio Perrone, Michela Fani, Andrea Aramini, Marcello Allegretti
Publikováno v:
ChemInform. 40
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key
Publikováno v:
Antiviral Research. 82:A29-A30
Autor:
Arnaud Gilles, Plinio Perrone, S. Chanberlain, Elena Gorovits, Yang Liu, Christopher McGuigan, Sabrina Holl, Geoffrey W. Henson, Jerry Muhammad, Alexander A. Kolykhalov, Jeff T. Hutchins, Karolina Madela, Andrea Hall, Babita Ganguly, Joseph M. Patti, C. Chang
Publikováno v:
Antiviral Research. 82:A28
Autor:
Plinio Perrone, Felice Daverio, Rocco Valente, Sonal Rajyaguru, Joseph A. Martin, Vincent Lévêque, Sophie Le Pogam, Isabel Najera, Klaus Klumpp, David B. Smith, Christopher McGuigan
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 22, p5463-5470, 8p
Autor:
Plinio Perrone, Giovanna M. Luoni, Mary Rose Kelleher, Felice Daverio, Annette Angell, Sinead Mulready, Costantino Congiatu, Sonal Rajyaguru, Joseph A. Martin, Vincent Levêque, Sophie Le Pogam, Isabel Najera, Klaus Klumpp, David B. Smith, Christopher McGuigan
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 8, p1840-1849, 10p