Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders.

Autor: Chen L; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Chen Y; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Zhang C; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Jiao B; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Liang S; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Tan Q; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Chai H; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Yu W; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Qian Y; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Yang H; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Yao W; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Yu J; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Luo Y; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States., Plewe M; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States., Wang J; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Han XR; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.; Cullgen (Shanghai), Inc., 230 ChuanHong Road, Building 6, Chuansha, Pudong New Area, Shanghai 201202, People's Republic of China., Liu J; Cullgen Inc., 12671 High Bluff Drive Suite 130, San Diego, California 92130, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Dec 10; Vol. 63 (23), pp. 14562-14575. Date of Electronic Publication: 2020 Oct 15.

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Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[ b , f ][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds.

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New beta-alanine derivatives are orally available glucagon receptor antagonists.

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Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line.

Autor: Akhter, Naheed¹ (AUTHOR), Batool, Sidra² (AUTHOR), Khan, Samreen Gul² (AUTHOR) samreengul@gcuf.edu, Rasool, Nasir² (AUTHOR), Anjum, Fozia² (AUTHOR), Rasul, Azhar³ (AUTHOR), Adem, Şevki⁴ (AUTHOR), Mahmood, Sadaf² (AUTHOR), Rehman, Aziz ur⁵ (AUTHOR), Nisa, Mehr un⁶ (AUTHOR), Razzaq, Zainib² (AUTHOR), Christensen, Jørn B.⁷ (AUTHOR), Abourehab, Mohammed A. S.⁸ (AUTHOR), Shah, Syed Adnan Ali^9,10 (AUTHOR) samreengul@gcuf.edu, Imran, Syahrul^10,11 (AUTHOR)

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