Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Pleuni S. Pennings"'
Autor:
Anjani Pradhananga, Lorena Benitez-Rivera, Candace Clark, Kaho H. Tisthammer, Pleuni S. Pennings
Publikováno v:
PeerJ, Vol 12, p e18178 (2024)
Over the last decades antibiotic resistance has evolved and spread in many different bacterial species. From an evolutionary perspective, drug resistance is an adaptation to a new environment. Population genetic theory predicts that recent adaptation
Externí odkaz:
https://doaj.org/article/c0ca03d6e40b473493cfe3c68772f3ce
Autor:
Meike T. Wortel, Deepa Agashe, Susan F. Bailey, Claudia Bank, Karen Bisschop, Thomas Blankers, Johannes Cairns, Enrico Sandro Colizzi, Davide Cusseddu, Michael M. Desai, Bram vanDijk, Martijn Egas, Jacintha Ellers, Astrid T. Groot, David G. Heckel, Marcelle L. Johnson, Ken Kraaijeveld, Joachim Krug, Liedewij Laan, Michael Lässig, Peter A. Lind, Jeroen Meijer, Luke M. Noble, Samir Okasha, Paul B. Rainey, Daniel E. Rozen, Shraddha Shitut, Sander J. Tans, Olivier Tenaillon, Henrique Teotónio, J. Arjan G. M. deVisser, Marcel E. Visser, Renske M. A. Vroomans, Gijsbert D. A. Werner, Bregje Wertheim, Pleuni S. Pennings
Publikováno v:
Evolutionary Applications, Vol 16, Iss 1, Pp 3-21 (2023)
Abstract Evolution has traditionally been a historical and descriptive science, and predicting future evolutionary processes has long been considered impossible. However, evolutionary predictions are increasingly being developed and used in medicine,
Externí odkaz:
https://doaj.org/article/5d350dba2ce2465ba41df12f9a33a44d
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3395-3407 (2019)
In the long-term neutral equilibrium, high rates of migration between subpopulations result in little population differentiation. However, in the short-term, even very abundant migration may not be enough for subpopulations to equilibrate immediately
Externí odkaz:
https://doaj.org/article/79aa93163c9349579627dac65c7a9b73
Autor:
Kaho H. Tisthammer, Christopher Kline, Tara Rutledge, Collin R. Diedrich, Sergio Ita, Philana Ling Lin, Zandrea Ambrose, Pleuni S. Pennings
Publikováno v:
Viruses, Vol 14, Iss 1, p 48 (2021)
Co-infection with Mycobacterium tuberculosis (Mtb) and human immunodeficiency virus (HIV) is a worldwide public health concern, leading to worse clinical outcomes caused by both pathogens. We used a non-human primate model of simian immunodeficiency
Externí odkaz:
https://doaj.org/article/3c10650b68364319a0e116a758b8a2e5
Publikováno v:
Viruses, Vol 13, Iss 3, p 511 (2021)
Understanding within-host evolution is critical for predicting viral evolutionary outcomes, yet such studies are currently lacking due to difficulty involving human subjects. Hepatitis C virus (HCV) is an RNA virus with high mutation rates. Its compl
Externí odkaz:
https://doaj.org/article/1f90eac2f7b24cfc9828a1d0f0762d23
Autor:
Pleuni S. Pennings
Publikováno v:
Infectious Disease Reports, Vol 5, Iss 1S, Pp e5-e5 (2013)
Access to combination antiretroviral treatment (ART) has improved greatly over recent years. At the end of 2011, more than eight million HIV-infected people were receiving ART in low-income and middle-income countries. ART generally works well in kee
Externí odkaz:
https://doaj.org/article/e12f868e6e55478bb1585298b862e8ba
Autor:
Kaho H Tisthammer, Caroline Solis, Faye Orcales, Madu Nzerem, Ryan Winstead, Weiyan Dong, Jeffrey B Joy, Pleuni S Pennings
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010179 (2022)
Like many viruses, Hepatitis C Virus (HCV) has a high mutation rate, which helps the virus adapt quickly, but mutations come with fitness costs. Fitness costs can be studied by different approaches, such as experimental or frequency-based approaches.
Externí odkaz:
https://doaj.org/article/b5e2d0b3c4bc4345896f48e4d4449ef2
Publikováno v:
eLife, Vol 10 (2021)
Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These therapies should prevent HIV drug resistance evolution, because one or more drugs suppress any partially resistant viruses. In practice, such therapies drastica
Externí odkaz:
https://doaj.org/article/68ca2701fe2d4c6da909973361d1453d
Publikováno v:
PLoS Genetics, Vol 15, Iss 3, p e1008035 (2019)
Evolutionary theory has produced two conflicting paradigms for the adaptation of a polygenic trait. While population genetics views adaptation as a sequence of selective sweeps at single loci underlying the trait, quantitative genetics posits a colle
Externí odkaz:
https://doaj.org/article/1ad9524c870f45e3af42785aa7bd765a
The manner in which costs associated with antibiotic resistance mutations are alleviated through the acquisition of compensatory mutations has bearing on the dynamics of resistance accumulation and spread as well as on our more general understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f5de66013a5b427c9f991614122ee4
https://doi.org/10.1101/2023.01.13.524028
https://doi.org/10.1101/2023.01.13.524028
