Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Pletsas, Dimitrios"'
Autor:
Pletsas, Dimitrios, Garelnabi, Elrashied A.E., Li, Li, Phillips, Roger M., Wheelhouse, Richard T.
Yes
The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.6
The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.6
Externí odkaz:
http://hdl.handle.net/10454/6135
Autor:
Garelnabi, Elrashied A.E., Pletsas, Dimitrios, Li, Li, Kiakos, K., Karodia, Nazira, Hartley, J.A., Phillips, Roger M., Wheelhouse, Richard T.
Yes
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% ef
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% ef
Externí odkaz:
http://hdl.handle.net/10454/7241
Autor:
Garelnabi, Elrashied A. E., Pletsas, Dimitrios, Li, Li, Kiakos, Konstantinos, Karodia, Nazira, Hartley, John A., Phillips, Roger M., Wheelhouse, Richard T.
Image The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% effic
Externí odkaz:
http://hdl.handle.net/10454/5984
The protein O6-alkylguanine-DNA alkyltransferase (Atase) is responsible for the repair of DNA lesions generated by several clinically important anti-cancer drugs; this is manifest as active resistance in those cancer cell lines proficient in Atase ex
Externí odkaz:
http://hdl.handle.net/10454/3168
A new and convenient method for the acid-catalysed Michael addition reactions of alcohols, thiols and amines to methyl vinyl ketone has been developed using the ionic liquid ethyltri-n-butylphosphonium tosylate. The reaction conditions are mild and o
Externí odkaz:
http://hdl.handle.net/10454/3694
Biarylpyrimidines are characterized as selective ligands for higher-order nucleic acid structures. A concise and efficient synthesis has been devised incorporating Suzuki biaryl cross-coupling of dihalopyrimidines. Two ligand series are described bas
Externí odkaz:
http://hdl.handle.net/10454/3150
Autor:
Vulpe, Georgeta, Liu, Guoyi, Oakley, Sam, Pletsas, Dimitrios, Yang, Guanghao, Dutra, Rosa, Guy, Owen, Liu, Yufei, Waldron, Mark, Neary, Joe, Mohan, Arjun Ajith, Sharma, Sanjiv
Publikováno v:
In Biosensors and Bioelectronics: X August 2024 19
Akademický článek
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Autor:
Pletsas, Dimitrios, Wheelhouse, Richard T., Pletsa, Vassiliki, Nicolaou, Anna, Jenkins, Terence C., Bibby, Michael C., Kyrtopoulos, Soterios A.
Publikováno v:
In European Journal of Medicinal Chemistry 2006 41(3):330-339
Autor:
Pletsas, Dimitrios, Garelnabi, Elrashied A. E., Li, Li, Phillips, Roger M., Wheelhouse, Richard T.
Publikováno v:
Journal of Medicinal Chemistry; Vol. 56 Issue 17, p7120-7132, 13p