Efficacy of a respiratory syncytial virus vaccine candidate in a maternal immunization model.

Autor: Blanco JCG; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA. j.blanco@sigmovir.com., Pletneva LM; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA., McGinnes-Cullen L; Department of Microbiology and Physiological Systems, Program of Immunology and Microbiology, University of Massachusetts Medical School, Worcester, MA, 01655, USA., Otoa RO; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA., Patel MC; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA., Fernando LR; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA., Boukhvalova MS; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD, 20850, USA., Morrison TG; Department of Microbiology and Physiological Systems, Program of Immunology and Microbiology, University of Massachusetts Medical School, Worcester, MA, 01655, USA.

Publikováno v: Nature communications [Nat Commun] 2018 May 15; Vol. 9 (1), pp. 1904. Date of Electronic Publication: 2018 May 15.

Preclinical assessment of safety of maternal vaccination against respiratory syncytial virus (RSV) in cotton rats.

Autor: Blanco JCG; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States. Electronic address: j.blanco@sigmovir.com., Pletneva LM; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States., Otoa RO; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States., Patel MC; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States., Vogel SN; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, United States., Boukhvalova MS; Sigmovir Biosystems Inc., 9610 Medical Center Drive, Suite 100, Rockville, MD 20850, United States.

Publikováno v: Vaccine [Vaccine] 2017 Jul 13; Vol. 35 (32), pp. 3951-3958. Date of Electronic Publication: 2017 Jun 16.

Novel strategies for targeting innate immune responses to influenza.

Autor: Shirey KA; Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland, USA., Lai W; Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland, USA., Patel MC; Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland, USA.; Sigmovir Biosystems, Rockville, Maryland, USA., Pletneva LM; Sigmovir Biosystems, Rockville, Maryland, USA., Pang C; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Kurt-Jones E; Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Lipsky M; Pathology Research, University of Maryland, Baltimore, Maryland, USA., Roger T; Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Calandra T; Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Tracey KJ; Department Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA., Al-Abed Y; Department of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, New York, USA., Bowie AG; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland., Fasano A; Mucosal Immunology and Biology Research Center, MGH for Children, Boston, Massachusetts, USA., Dinarello CA; Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado, USA., Gusovsky F; Eisai, Andover, Massachusetts, USA., Blanco JC; Sigmovir Biosystems, Rockville, Maryland, USA., Vogel SN; Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland, USA.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2016 Sep; Vol. 9 (5), pp. 1173-82. Date of Electronic Publication: 2016 Jan 27.

Agents that increase AAM differentiation blunt RSV-mediated lung pathology.

Autor: Shirey KA; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA;, Lai W; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA;, Pletneva LM; Sigmovir Biosystems, Inc., Rockville, Maryland, USA;, Finkelman FD; Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA; Division of Allergy, Immunology and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; and., Feola DJ; University of Kentucky, College of Pharmacy, Lexington, Kentucky, USA., Blanco JC; Sigmovir Biosystems, Inc., Rockville, Maryland, USA;, Vogel SN; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA; svogel@som.umaryland.edu.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2014 Dec; Vol. 96 (6), pp. 951-5. Date of Electronic Publication: 2014 Jul 09.

Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology.

Autor: Shirey KA; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA., Lai W; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA., Pletneva LM; Sigmovir Biosystems, Inc., Rockville, Maryland, USA., Karp CL; Division of Cellular and Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA., Divanovic S; Division of Cellular and Molecular Immunology, Cincinnati Children's Hospital Research Foundation, Cincinnati, Ohio, USA., Blanco JC; Sigmovir Biosystems, Inc., Rockville, Maryland, USA., Vogel SN; Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland, USA.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2014 May; Vol. 7 (3), pp. 549-57. Date of Electronic Publication: 2013 Sep 25.