Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor.

Autor: Keller, Sascha, Kunz, Ulrich, Schmid, Ulrike, Beusmans, Jack, Büchert, Martin, He, Min, Jayadeva, Girish, Le Tourneau, Christophe, Luedtke, Doreen, Niessen, Heiko G., Oum'hamed, Zohra, Pleiner, Sina, Wang, Xiaoning, Graeser, Ralph

Publikováno v: Journal of Translational Medicine; 10/14/2024, Vol. 22 Issue 1, p1-18, 18p

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Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway.

Autor: Küster OC; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany.; Department of Neurology, Ulm University, Germany., Laptinskaya D; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany., Fissler P; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany.; Department of Neurology, Ulm University, Germany., Schnack C; Department of Neurology, Ulm University, Germany., Zügel M; Department of Internal Medicine, Division of Sports Medicine, University Hospital Ulm, Germany., Nold V; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany.; Boehringer Ingelheim Pharma GmbH & Co. KG, DMPK, Biberach an der Riss, Germany., Thurm F; Department of Psychology, TU Dresden, Germany., Pleiner S; Boehringer Ingelheim Pharma GmbH & Co. KG, DMPK, Biberach an der Riss, Germany., Karabatsiakis A; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany., von Einem B; Department of Neurology, Ulm University, Germany., Weydt P; Department of Neurology, Ulm University, Germany., Liesener A; Boehringer Ingelheim Pharma GmbH & Co. KG, DMPK, Biberach an der Riss, Germany., Borta A; Boehringer Ingelheim Pharma GmbH & Co. KG, DMPK, Biberach an der Riss, Germany., Woll A; Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Germany., Hengerer B; Boehringer Ingelheim Pharma GmbH & Co. KG, RES CNS, Biberach an der Riss, Germany., Kolassa IT; Institute of Psychology and Education, Clinical and Biological Psychology, Ulm University, Germany., von Arnim CAF; Department of Neurology, Ulm University, Germany.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2017; Vol. 59 (3), pp. 1097-1111.