Výsledky vyhledávání - "Pleasure David"

Akademický článek

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia

Autor: Horiuchi Makoto, Wakayama Kouji, Itoh Aki, Kawai Kumi, Pleasure David, Ozato Keiko, Itoh Takayuki

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 227 (2012)

Abstract Background Recent fate-mapping studies establish that microglia, the resident mononuclear phagocytes of the CNS, are distinct in origin from the bone marrow-derived myeloid lineage. Interferon regulatory factor 8 (IRF8, also known as interfe

Externí odkaz: https://doaj.org/article/fb53bc9b879646f09706eb98a22a03e3

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Akademický článek

IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci

Autor: Lee Eunyoung, Chanamara Sarah, Pleasure David, Soulika Athena M

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 7 (2012)

Abstract Background Murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, presents typically as ascending paralysis. However, in mice in which interferon-gamma (IFNγ) signaling is disrupted by genetic deletion, limb

Externí odkaz: https://doaj.org/article/18cf49be92a946798ad22a713bb149ae

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Akademický článek

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells

Autor: Pleasure David, Itoh Aki, Horiuchi Makoto, Ozato Keiko, Itoh Takayuki

Publikováno v: Journal of Neuroinflammation, Vol 8, Iss 1, p 8 (2011)

Abstract Background Administration of exogenous interferon-γ (IFNγ) aggravates the symptoms of multiple sclerosis (MS), whereas interferon-β (IFNβ) is used for treatment of MS patients. We previously demonstrated that IFNγ induces apoptosis of o

Externí odkaz: https://doaj.org/article/d490bd1ab5894a388a276d4bc9c19783

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