Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Pleasance, P."'
Publikováno v:
New J. Phys. 26, 073025 (2024)
We apply the hierarchical equations of motion technique to analyzing nonequilibrium heat transport in a spin-boson type model, whereby heat transfer through a central spin is mediated by an intermediate pair of coupled harmonic oscillators. The coupl
Externí odkaz:
http://arxiv.org/abs/2403.13904
Autor:
Yuka Takemon, Erin D. Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmok, Kathleen Wee, Diane L. Trinh, Ryan D. Huff, Andrew J. Mungall, Richard A. Moore, Eric Chuah, Karen L. Mungall, Eleanor Lewis, Jessica Nelson, Howard J. Lim, Daniel J. Renouf, Steven JM. Jones, Janessa Laskin, Marco A. Marra
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-31 (2024)
Abstract Background Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted. Approaches characterising gene function and vulnerabilities conferred by such mutations are required. Methods Here, we computationally map
Externí odkaz:
https://doaj.org/article/2954f6a10f424393a3fd559481966131
Publikováno v:
Phys. Rev. Applied 20, 024038 (2023)
While strong system-bath coupling produces rich and interesting phenomena, applications to quantum thermal engines have been so far pointing mainly at detrimental effects. The delicate trade-off between efficiency loss due to strong coupling and powe
Externí odkaz:
http://arxiv.org/abs/2304.03267
Autor:
Rebecca J. Deyell, Yaoqing Shen, Emma Titmuss, Katherine Dixon, Laura M. Williamson, Erin Pleasance, Jessica M. T. Nelson, Sanna Abbasi, Martin Krzywinski, Linlea Armstrong, Melika Bonakdar, Carolyn Ch’ng, Eric Chuah, Chris Dunham, Alexandra Fok, Martin Jones, Anna F. Lee, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Paul C. Rogers, Kasmintan A. Schrader, Alice Virani, Kathleen Wee, Sean S. Young, Yongjun Zhao, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Shahrad R. Rassekh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The role for routine whole genome and transcriptome analysis (WGTA) for poor prognosis pediatric cancers remains undetermined. Here, we characterize somatic mutations, structural rearrangements, copy number variants, gene expression, immuno-
Externí odkaz:
https://doaj.org/article/7e4974acf7f14999a67996f77a1aac77
Autor:
Emma Titmuss, Irene S. Yu, Erin D. Pleasance, Laura M. Williamson, Karen Mungall, Andrew J. Mungall, Daniel J. Renouf, Richard Moore, Steven J. M. Jones, Marco A. Marra, Janessa J. Laskin, Kerry J. Savage
Publikováno v:
Current Oncology, Vol 31, Iss 4, Pp 1865-1875 (2024)
Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead
Externí odkaz:
https://doaj.org/article/165bce1a3d6f4c00a9c7740f49ec203b
We outline a non-perturbative approach for simulating the behavior of open quantum systems interacting with a bosonic environment defined by a generalized spectral density function. The method is based on replacing the environment by a set of damped
Externí odkaz:
http://arxiv.org/abs/2108.05755
Publikováno v:
Phys. Rev. Research 2, 043058 (2020)
We develop an exact framework to describe the non-Markovian dynamics of an open quantum system interacting with an environment modeled by a generalized spectral density function. The approach relies on mapping the initial system onto an auxiliary con
Externí odkaz:
http://arxiv.org/abs/2002.09739
Akademický článek
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Akademický článek
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Autor:
Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and transcriptomic (RNA-Seq) data
Externí odkaz:
https://doaj.org/article/94cf2e36a62f41e6b8a8f4c6c8888bcf