Confining Trypanosoma brucei in emulsion droplets reveals population variabilities in division rates and improves in vitro cultivation

Autor: Allmann, Stefan, Wargnies, Marion, Plazolles, Nicolas, Cahoreau, Edern, Biran, Marc, Morand, Pauline, Pineda, Erika, Kulyk, Hanna, Asencio, Corinne, Villafraz, Oriana, Rivière, Loïc, Tetaud, Emmanuel, Rotureau, Brice, Mourier, Arnaud, Portais, Jean-Charles, Dé Ric Bringaud, Fré, Oldenburg, Simone, Buisson, Lionel, Beneyton, Thomas, Pekin, Deniz, Thonnus, Magali, Bringaud, Frédéric, Baret, Jean-Christophe

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-97356-7⟩

Trypanosome parasites are infecting mammals in Sub-Saharan Africa and are transmitted between hosts through bites of the tsetse fly. The transmission from the insect vector to the mammal host causes a number of metabolic and physiological changes. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4d0a2b6a59a3c2bcc12e85253888cb
https://doaj.org/article/e0705906537b426d891347e2de812905

Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

Autor: Wargnies, Marion, Plazolles, Nicolas, Schenk, Robin, Villafraz, Oriana, Dupuy, Jean-William, Biran, Marc, Bachmaier, Sabine, Baudouin, Hélène, Clayton, Christine, Boshart, Michael, Bringaud, Frédéric

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100548. ⟨10.1016/j.jbc.2021.100548⟩
The Journal of Biological Chemistry

International audience; The genome of trypanosomatids rearranges by using repeated sequences as platforms for amplification or deletion of genomic segments. These stochastic recombination events have a direct impact on gene dosage and foster the sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::432b54ef02595b3c3feb09753cee04e9
https://hal.archives-ouvertes.fr/hal-03216701

Gluconeogenesis is essential for trypanosome development in the tsetse fly vector

Autor: Wargnies, Marion, Bertiaux, Eloise, Cahoreau, Edern, Ziebart, Nicole, Crouzols, Aline, Morand, Pauline, Biran, Marc, Allmann, Stefan, Hubert, Jane, Villafraz, Oriana, Millerioux, Yoann, Plazolles, Nicolas, Asencio, Corinne, Rivière, Loïc, Rotureau, Brice, Boshart, Michael, Portais, Jean-Charles, Bringaud, Frédéric

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2018, 14 (12), pp.e1007502. ⟨10.1371/journal.ppat.1007502⟩
PLoS Pathogens, Public Library of Science, 2018, 14 (12), pp.e1007502. ⟨10.1371/journal.ppat.1007502⟩
Plos Pathogens 12 (14), 28 p.. (2018)
PLoS Pathogens, Vol 14, Iss 12, p e1007502 (2018)

In the glucose-free environment that is the midgut of the tsetse fly vector, the procyclic form of Trypanosoma brucei primarily uses proline to feed its central carbon and energy metabolism. In these conditions, the parasite needs to produce glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e78bc6ed03e245c970adcf2eddadbbd
https://hal-pasteur.archives-ouvertes.fr/pasteur-01963538/file/journal.ppat.1007502.pdf

Identification of Trans-Sialidases as a Common Mediator of Endothelial Cell Activation by African Trypanosomes.

Autor: Ammar, Zeinab¹, Plazolles, Nicolas¹, Baltz, Théo¹, Coustou, Virginie¹ virginie.coustou@u-bordeaux2.fr

Publikováno v: PLoS Pathogens. Oct2013, Vol. 9 Issue 10, p1-16. 16p.

Sialidases play a key role in infection and anaemia in Trypanosoma congolense animal trypanosomiasis.

Autor: Coustou, Virginie^1,2, Plazolles, Nicolas^1,2, Guegan, Fabien^1,2, Baltz, Théo^1,2

Publikováno v: Cellular Microbiology. Mar2012, Vol. 14 Issue 3, p431-445. 15p. 2 Diagrams, 4 Graphs.