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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 .

Autor: Bothe U; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Günther J; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Nubbemeyer R; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Siebeneicher H; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Ring S; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Bömer U; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Peters M; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Rausch A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Denner K; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Himmel H; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Sutter A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Terebesi I; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Lange M; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Wengner AM; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Guimond N; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Thaler T; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Platzek J; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Eberspächer U; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Schäfer M; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Steuber H; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Zollner TM; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Steinmeyer A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Schmidt N; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1225-1242. Date of Electronic Publication: 2024 Jan 16.

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Enantioselective Total Synthesis of (-)-Finerenone Using Asymmetric Transfer Hydrogenation.

Autor: Lerchen A; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK., Gandhamsetty N; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK., Farrar EHE; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Winter N; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK., Platzek J; Chemical Development, Bayer AG, 42096, Wuppertal, Germany., Grayson MN; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Aggarwal VK; School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Dec 14; Vol. 59 (51), pp. 23107-23111. Date of Electronic Publication: 2020 Nov 23.

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Clinical Properties and Non-Clinical Testing of Mineralocorticoid Receptor Antagonists in In Vitro Cell Models.

Autor: Varda, Luka¹ (AUTHOR) luka.varda@gmail.com, Ekart, Robert^1,2 (AUTHOR) robert.ekart2@guest.arnes.si, Lainscak, Mitja^3,4 (AUTHOR) mitja.lainscak@guest.arnes.si, Maver, Uroš^2,5 (AUTHOR), Bevc, Sebastjan^2,6 (AUTHOR) sebastjan.bevc@ukc-mb.si

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p9088. 21p.

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Whole Cancer Visualization using Gadobutrol-glucose Solution and 7.0 T Magnetic Resonance Imaging.

Autor: Manabu Watanabe¹, Eiichi Sato² dresato@iwate-med.ac.jp, Jiro Sato¹, Kazuki Ito¹, Hodaka Moriyama¹, Osahiko Hagiwara¹, Toshiyuki Enomoto¹, Ryoko Yoshida³, Susumu Hayakawa³, Yuichi Sato³, Sohei Yoshida², Kunihiro Yoshioka², Hiroyuki Nitta²

Publikováno v: Journal of Medical Physics. Jul-Sep2024, Vol. 49 Issue 3, p427-432. 6p.

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Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro.

Autor: Gerisch M; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany michael.gerisch@bayer.com., Heinig R; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Engelen A; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Lang D; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Kolkhof P; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Radtke M; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Platzek J; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Lovis K; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Rohde G; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany., Schwarz T; Drug Metabolism and Pharmacokinetics (M.G., A.E., D.L., M.R., G.R., T.S.), Clinical Sciences (R.H.), Cardiology Research (P.K.), and Pharmaceutical Development (J.P., K.L.), Bayer AG, Wuppertal, Germany.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2018 Nov; Vol. 46 (11), pp. 1546-1555. Date of Electronic Publication: 2018 Aug 31.

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