Aggregation of platelets, proliferation of endothelial cells and motility of cancer cells are mediated by the B?1(15)-42 residue of fibrin(ogen)

Autor: V. O. Chernyshenko, Y. M. Stohnii, Platonova Tm, L. V. Garmanchuk, M. V. Ryzhykova, N. M. Lypova, A. V. Rebriev, M. D. Kuchma, Serhiy Komisarenko, O. Yu. Slominskyi, V. A. Shablii, R. Y. Marunych

Publikováno v: Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 72-84 (2020)

The fibrinogen molecule contains multiple binding motifs for different types of cellular receptors, acting as a molecular link between coagulation and cell adhesion. In this study we generated a truncated form of the fibrinogen molecule lacking the B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77befe8bdf4cbf235cea6e5c9589653
https://doi.org/10.15407/ubj92.02.072

Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom

Autor: Liudmyla V. Garmanchuk, E. V. Lugovskoy, Platonova Tm, V. O. Chernyshenko, Chernyshenko Tm, Ludmila Kasatkina, O. V. Gornytska, O. I. Dzhus, D S Korolova, Natalia Petruk, Andriy Rebriev

Publikováno v: Croatian Medical Journal

Aim To purify the platelet aggregation inhibitor from Echis multisquamatis snake venom (PAIEM) and characterize its effect on platelet aggregation and HeLa cell proliferation. Methods Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eafbcd9602cb2c66af748d019c6d1e4
https://doi.org/10.3325/cmj.2017.58.118

Non-enzymatic activation of prothrombin induced by interaction with fibrin β26-42 region

Autor: V. O. Chernyshenko, Iryna N Kolesnikova, Galyna P Volynets, E. V. Lugovskoy, Chernyshenko Tm, D S Korolova, Platonova Tm

Publikováno v: Acta Biochimica Polonica. 62:517-522

We have discovered that addition of monomeric desAB fibrin to prothrombin leads to appearance of the thrombin-like activity of prothrombin towards S2238 chromogenic substrate. DesA and desABβ(15-42)2 fibrin forms did not cause any activation of prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2000e4360bf7e23e8c46711be0e21526
https://doi.org/10.18388/abp.2014_896

A new fibrinogenase from Echis multisquamatis venom is a perspective agent for limited proteolysis and defibrinogenation

Autor: Platonova Tm, Liudmyla I. Sokolovska, V. O. Chernyshenko, O. V. Gornytska

Publikováno v: Advances in Bioscience and Biotechnology. :91-96

A serine proteinase with a fibrinogenase activity was isolated from the venom of viper Echis multisquamatis. Isolation was performed by the combination of Q-sepharose and Heparine-agarose chromatography. The enzyme has apparent molecular weight 35 ±

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a8f9e67dd008803b00190b707cf9d80
https://doi.org/10.4236/abb.2010.12013

Decrease of prothrombin level during thrombolysis in acute myocardium infarction.

Autor: Korolova DS; Palladin Institute of Biochemistry, National Academy of Science of Ukraine., Parkhomenko AM; State Institutional Scientific Center The M.D. Strazhesko Institute of Cardiology, Clinical and Regenerative Medicine of The National Academy of Medical Sciences of Ukraine., Chernyshenko V; Palladin Institute of Biochemistry, National Academy of Science of Ukraine., Chernyshenko TM; Palladin Institute of Biochemistry, National Academy of Science of Ukraine., Druzhyna NM; Palladin Institute of Biochemistry, National Academy of Science of Ukraine., Hornytska OV; Palladin Institute of Biochemistry, National Academy of Science of Ukraine., Platonova TM; Palladin Institute of Biochemistry, National Academy of Science of Ukraine.

Publikováno v: Acta biochimica Polonica [Acta Biochim Pol] 2023 Nov 27; Vol. 70 (4), pp. 991-995.