Zobrazeno 1 - 10
of 2 446
pro vyhledávání: '"Platinum resistance"'
Autor:
Franziska Maria Schwarz, Jan Dominik Kuhlmann, Jorrin Kämpfer, Anna Klimova, Daniel Martin Klotz, Lisa Freitag, Pia Herrmann, Viktoria Zinnow, Janice Smith, Theresia Scheller, Wolfgang Walther, Pauline Wimberger, Ulrike Stein
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract The drug efflux transporter P-glycoprotein, encoded by the ABCB1 gene, promotes acquired chemoresistance. We explored the presence and clinical relevance of circulating cell-free ABCB1 transcripts (cfABCB1tx) in ovarian cancer patients (173
Externí odkaz:
https://doaj.org/article/bbbc1b0b2f144c9cb8c3f0c9409951ea
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background This study aimed to develop a novel nomogram that can accurately estimate platinum resistance to enhance precision medicine in epithelial ovarian cancer(EOC). Methods EOC patients who received primary therapy at the General Hospit
Externí odkaz:
https://doaj.org/article/6036ccd8171145509062d8e17c7979a9
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-23 (2024)
Abstract Background Ovarian cancer (OC) has the worst prognosis among gynecological malignancies, most of which are found to be in advanced stage. Cell reduction surgery based on platinum-based chemotherapy is the current standard of treatment for OC
Externí odkaz:
https://doaj.org/article/87141f573a6346e69243b366dd998c10
Publikováno v:
IEEE Access, Vol 12, Pp 41000-41008 (2024)
Ovarian cancer is one of the three most common types of gynecological cancer globally, with high-grade serous ovarian cancer being the most common and aggressive histological type. Guided treatment of high-grade serous ovarian cancer typically involv
Externí odkaz:
https://doaj.org/article/c324c4cbde7b45d986e5ea405f62b7a7
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Most patients with ovarian cancer (OC) treated with platinum-based chemotherapy have a dismal prognosis owing to drug resistance. However, the regulatory mechanisms of circular RNA (circRNA) and p53 ubiquitination are unknown in p
Externí odkaz:
https://doaj.org/article/9621071e1578457487d86e59f183375d
Publikováno v:
Heliyon, Vol 10, Iss 11, Pp e31835- (2024)
During the measurement of multiphase flow in low yield oil wells, the liquid volume will vary with the operating characteristics of the pumping unit. Using the pulsating characteristics of the up and down strokes of a pumping unit, the flow rate is m
Externí odkaz:
https://doaj.org/article/2d7b3b4507264e3198e2d2e04cac048c
Autor:
Heidi Rausio, Alejandra Cervera, Vanina D. Heuser, Gun West, Jaana Oikkonen, Elena Pianfetti, Marta Lovino, Elisa Ficarra, Pekka Taimen, Johanna Hynninen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Kaisa Huhtinen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 51, Iss , Pp 100987- (2024)
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified fr
Externí odkaz:
https://doaj.org/article/2d652944943a4b03bb95ad24b38668fe
Autor:
Yinan Jiang, Shuting Huang, Lan Zhang, Yun Zhou, Wei Zhang, Ting Wan, Haifeng Gu, Yi Ouyang, Xiaojing Zheng, Pingping Liu, Baoyue Pan, Huiling Xiang, Mingxiu Ju, Rongzhen Luo, Weihua Jia, Shenjiao Huang, Jundong Li, Min Zheng
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Platinum resistance represents a major barrier to the survival of patients with ovarian cancer (OC). Cdc2‐like kinase 2 (CLK2) is a major protein kinase associated with oncogenic phenotype and development in some solid tumors. However, the
Externí odkaz:
https://doaj.org/article/63c66995e9f74acb8dc4f1c26dc6742a
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-18 (2023)
Abstract Background Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate of 30%-50%. Platinum resistance is the chief culprit for the high recurrence and mortality rates. Several st
Externí odkaz:
https://doaj.org/article/d4aebbef01e34c48bda74135becf498d
Autor:
Theresa Guo, Fernando Zamuner, Stephanie Ting, Liam Chen, Lisa Rooper, Pablo Tamayo, Carole Fakhry, Daria Gaykalova, Ranee Mehra
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionMost patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment. However, up to 25% of patients with HPV-positive OPSCC wi
Externí odkaz:
https://doaj.org/article/20601af582144e90aa2dc3a87e5a3045