Glycoprotein Ib clustering in platelets can be inhibited by α-linolenic acid as revealed by cryo-electron tomography

Autor: Jürg H. Beer, Nicole R. Bonetti, Simona Stivala, Thomas F. Lüscher, Sara Gobbato, Ohad Medalia, Giovanni G. Camici, Simona Sorrentino

Publikováno v: Haematologica

Platelet adhesion to the sub-endothelial matrix and damaged endothelium occurs through a multi-step process mediated in the initial phase by glycoprotein Ib binding to von Willebrand factor (vWF), which leads to the subsequent formation of a platelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0f5f54cc27e67e3fb5f0d52f97e199
http://europepmc.org/articles/PMC7271563

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Autor: Hervé Falet, Jon Wieser, Adam D. Munday, Caleb Drew, Nathan Eaton

Publikováno v: Haematologica

Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2. Here, the role of dynamin 2 was inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526c9fa769cdc8819d03fb79654074a8
https://doi.org/10.3324/haematol.2019.218644

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

Autor: Remco Verdoold, Joana Batista, Sanne L. N. Brouns, Marijke J.E. Kuijpers, Mattia Frontini, Johanna P. van Geffen, Suthesh Sivapalaratnam, Harriet McKinney, Magdolna Nagy, Constance C.F.M.J. Baaten, Frauke Swieringa, Rachel Cavill, Kerstin Jurk, Johan W. M. Heemskerk, Carly Kempster, Manuela Krause, Willem H. Ouwehand, Daniele Pillitteri, Nikki Bourry, Kate Downes

Publikováno v: Haematologica 104(6), 1256-1267 (2019). doi:10.3324/haematol.2018.198853
Haematologica
Haematologica-the Hematology Journal, 104(6), 1256-1267. Ferrata Storti Foundation

In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter-and intra-subject variability in parameters of microspot-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d3d8e77a0f55bc6a799fa2baf26289
https://doi.org/10.3324/haematol.2018.198853

All-trans retinoic acid protects mesenchymal stem cells from immune thrombocytopenia by regulating the complement–interleukin-1β loop

Autor: Ying-Jun Chang, Ming Hou, Xiao-Lu Zhu, Hao Jiang, Ya-Nan Wang, Jun Peng, Xiao-Jun Huang, Jin Lu, Ya-Zhe Wang, Yuan Kong, Xiao-Hui Zhang, Qian Jiang, Lan-Ping Xu

Publikováno v: Haematologica

Enhanced peripheral complement activation has long been considered as one of the major pathogenic elements of immune thrombocytopenia. A dysfunctional bone marrow microenvironment, especially with regards to mesenchymal stem cells, has been observed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4eb84798e8d44f4b4062a0154679a22
https://doi.org/10.3324/haematol.2018.204446

Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura

Autor: Radhika Gangaraju, Nicole K. Kocher, Chong H. Kim, Lance A. Williams, X. Long Zheng, Wenjing Cao, Marisa B. Marques, Robin G. Lorenz, Elizabeth M. Staley, Huy P. Pham, Lucy Zheng

Publikováno v: Haematologica

Immune-mediated thrombotic thrombocytopenic purpura is characterized by severe thrombocytopenia and microangiopathic hemolytic anemia. It is primarily caused by immunoglobin G type autoantibodies against ADAMTS13, a plasma metalloprotease that cleave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d2241c1a773359e89202bb526cae5
http://europepmc.org/articles/PMC6312039