Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Plamen P. Christov"'
Selective Incision of the α-N5-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV
Publikováno v:
Journal of Nucleic Acids, Vol 2010 (2010)
Formamidopyrimidines (Fapy) lesions result from ring opening of the imidazole portion of purines. Fapy lesions can isomerize from the natural β-anomeric stereochemistry to the α-configuration. We have unambiguously demonstrated that the α-methyl-F
Externí odkaz:
https://doaj.org/article/ff4f5122b16e47a0b68394a152044871
Autor:
Kevin P. Kelly, Hugo Borsetti, Marta E. Wenzler, Alessandro Ustione, Kwangho Kim, Plamen P. Christov, Bianca Ramirez, Joshua A. Bauer, David W. Piston, Carl Hirschie Johnson, Gary A. Sulikowski
Publikováno v:
ACS Chem Biol
A high-throughput cell-based screen identified redox-active small molecules that produce a period lengthening of the circadian rhythm. The strongest period lengthening phenotype was induced by a phenazine carboxamide (VU661). Comparison to two isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81eac32d691a448f27578095b63aa4cb
https://doi.org/10.1021/acschembio.2c00240
https://doi.org/10.1021/acschembio.2c00240
Autor:
Lihong Wang-Bishop, Blaise R. Kimmel, Verra M. Ngwa, Matthew Z. Madden, Jessalyn J. Baljon, David C. Florian, Ann Hanna, Lucinda E. Pastora, Taylor L. Sheehy, Alexander J. Kwiatkowski, Mohamed Wehbe, Xiaona Wen, Kyle W. Becker, Kyle M. Garland, Jacob A. Schulman, Daniel Shae, Deanna Edwards, Melissa M. Wolf, Rossane Delapp, Plamen P. Christov, Kathryn E. Beckermann, Justin M. Balko, W. Kimryn Rathmell, Jeffrey C. Rathmell, Jin Chen, John T. Wilson
Publikováno v:
Science Immunology. 8
The tumor-associated vasculature imposes major structural and biochemical barriers to the infiltration of effector T cells and effective tumor control. Correlations between stimulator of interferon genes (STING) pathway activation and spontaneous T c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ce565876a4da8969c5cc85811cb4a2
https://doi.org/10.1126/sciimmunol.add1153
https://doi.org/10.1126/sciimmunol.add1153
Autor:
Philip J. Kingsley, Carmelo J. Rizzo, Plamen P. Christov, Kwangho Kim, Anoop Vemulapalli, Robert L. Eoff, Carol A. Rouzer, Amit Ketkar, Lawrence J. Marnett, Gary A. Sulikowski, Robyn Richie-Jannetta
Publikováno v:
Chemical Research in Toxicology. 34:2567-2578
The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M1dG. This mutagenic lesion has been found in human genomic and mitochondrial DNA. M1dG in genomic DNA is en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164ccb69984ddbd58c064415de894d3f
https://doi.org/10.1021/acs.chemrestox.1c00334
https://doi.org/10.1021/acs.chemrestox.1c00334
Autor:
Walter J. Chazin, Alex G. Waterson, Rocco D. Gogliotti, Natalia Kozlyuk, Plamen P. Christov, Benjamin A. Gilston, Lauren E. Salay, Mohiuddin Ovee, Kwangho Kim
Publikováno v:
Proteins
The Receptor for Advanced Glycation End products (RAGE) is a pattern recognition receptor that signals for inflammation via the NF-κB pathway. RAGE has been pursued as a potential target to suppress symptoms of diabetes and is of interest in a numbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcfa1890d331293f2c5bdde515a3253e
https://doi.org/10.1002/prot.26162
https://doi.org/10.1002/prot.26162
Autor:
Plamen P. Christov, Benjamin Guttentag, Alex G. Waterson, Craig W. Lindsley, Kwangho Kim, Brendan F. Dutter, Alexander P. Lamers, Somnath Jana, Kyouk Jeon, Jianhua Tian, Toya Scaggs, Ian M. Romaine, Gary A. Sulikowski, C. David Weaver
Publikováno v:
ACS Chemical Biology. 16:787-793
Chemical synthesis has been described as a central science. Its practice provides access to the chemical structures of known and/or designed function. In particular, human health is greatly impacted by synthesis that enables advancements in both basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda91fe7da46020aade57c51fe73148e
https://doi.org/10.1021/acschembio.0c00818
https://doi.org/10.1021/acschembio.0c00818
Autor:
Mohamed Wehbe, Plamen P. Christov, Carcia S. Carson, Jessalyn J. Baljon, Kyle W. Becker, Christian R. Palmer, Sebastian Joyce, Frances C. Knight, Naveenchandra Suryadevara, Amrendra Kumar, John T. Wilson, Daniel Shae
Publikováno v:
ACS Nano
Cancer vaccines targeting patient-specific neoantigens have emerged as a promising strategy for improving responses to immune checkpoint blockade. However, neoantigenic peptides are poorly immunogenic and inept at stimulating CD8(+) T cell responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b62f24cd974058648e5318fe44f673
https://doi.org/10.1021/acsnano.0c02765
https://doi.org/10.1021/acsnano.0c02765
Autor:
Plamen P, Christov, Robyn, Richie-Jannetta, Philip J, Kingsley, Anoop, Vemulapalli, Kwangho, Kim, Gary A, Sulikowski, Carmelo J, Rizzo, Amit, Ketkar, Robert L, Eoff, Carol A, Rouzer, Lawrence J, Marnett
Publikováno v:
Chemical research in toxicology. 34(12)
The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ec6c6dd254cc504dbea58cc6e345048
https://pubmed.ncbi.nlm.nih.gov/34860508
https://pubmed.ncbi.nlm.nih.gov/34860508
Autor:
Terri T. Ni, Xuejiao Zhu, Kaa Seng Lai, Leah M. Sawyer, Xueli Hu, Chunyu Zeng, Wenbin Fu, Gary A. Sulikowski, Tao P. Zhong, Wei E Wang, Guangju Yu, Yating Zhou, Plamen P. Christov, Zhongzhou Yang, Xiangwen Peng, Ethan Lee, Shuying Xie
Publikováno v:
J Mol Cell Biol
There are intense interests in discovering proregenerative medicine leads that can promote cardiac differentiation and regeneration, as well as repair damaged heart tissues. We have combined zebrafish embryo-based screens with cardiomyogenesis assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0936c9bd7c2a8cb711d58cb606d614
https://doi.org/10.1093/jmcb/mjz023
https://doi.org/10.1093/jmcb/mjz023
Autor:
Evan Perry, Jonathan J. Mills, Bin Zhao, Feng Wang, Qi Sun, Plamen P. Christov, James C. Tarr, Tyson A. Rietz, Edward T. Olejniczak, Taekyu Lee, Stephen Fesik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:786-790
The PD-1 immune checkpoint pathway is a highly validated target for cancer immunotherapy. Despite the potential ad-vantages of small molecule inhibitors over antibodies, the discovery of small molecule checkpoint inhibitors has lagged behind. To disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bcca539b2b0afed20db8628919eeae8
https://doi.org/10.1016/j.bmcl.2019.01.028
https://doi.org/10.1016/j.bmcl.2019.01.028