Výsledky vyhledávání

Quiescence as a mechanism for cyclical hypoxia and acidosis

Autor: K. Smallbone, DJ Gavaghan, PK Maini, JM Brady

Publikováno v: JOURNAL OF MATHEMATICAL BIOLOGY. 55(5)

Tumour tissue characteristically experiences fluctuations in substrate supply. This unstable microenvironment drives constitutive metabolic changes within cellular populations and, ultimately, leads to a more aggressive phenotype. Previously, variati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::008df8d1ce2db8fbed479b2a917636cd
http://ora.ox.ac.uk/objects/uuid:4ecee97d-a1cb-4974-bb9a-134b3d2bffd5

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Metabolic changes during carcinogenesis: Potential impact on invasiveness

Autor: K. Smallbone, RA Gatenby, RJ Gillies, PK Maini, DJ Gavaghan

Publikováno v: JOURNAL OF THEORETICAL BIOLOGY. 244(4)

Successful adaptation to varying microenvironmental constraints plays a crucial role during carcinogenesis. We develop a hybrid cellular automation approach to investigate the cell-microenvironmental interactions that mediate somatic evolution of can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::a1a37c03ff7567e7e757dd528ac0140e
http://ora.ox.ac.uk/objects/uuid:8b9234cc-0a21-4e23-b197-aece7057509f

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Biomathematical modelling II − Preface

Autor: P. Kohl, A. Garny, PK Maini, DJ Gavaghan

Publikováno v: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A−MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 364(1843)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64da1ce90f98c8341fb4b2b73b81c7c2
http://ora.ox.ac.uk/objects/uuid:8d7c53e8-f104-49be-8f50-6601f4d0704e

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Mathematical models in physiology

Autor: DJ Gavaghan, A. Garny, PK Maini, P. Kohl

Publikováno v: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A−MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 364(1842)

Computational modelling of biological processes and systems has witnessed a remarkable development in recent years. The search-term (modelling OR modeling) yields over 58 000 entries in PubMed. with more than 34 000 since the year 2000: thus, almost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::12fdaba5b28ab55d4d4f15f542054038
http://ora.ox.ac.uk/objects/uuid:cd678ac0-a80a-469e-8682-aafd83be0b08

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role of acidity in solid tumour growth and invasion

Autor: K. Smallbone, DJ Gavaghan, RA Gatenby, PK Maini

Publikováno v: Journal of theoretical biology. 235(4)

Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::f5d2bd5a11142c652d642addd9a0b01e
http://ora.ox.ac.uk/objects/uuid:311e7863-5e92-45b9-b108-08010d4d8916

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Modelling rain forest diversity: The role of competition

Autor: CJ Bampfylde, ND Brown, DJ Gavaghan, PK Maini

Publikováno v: Ecological Modelling. 188(2)

Rain forests exhibit enormous species diversity, but the mechanisms for establishing and maintaining such diversity are unknown. Models involving both exploitative and pre-emptive competition have been proposed. We examine two of these models mathema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::d5998afdaa84835fbf111ae9cc936b65
http://ora.ox.ac.uk/objects/uuid:d8b015fb-c56e-4157-a40b-2227bf752057

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cell cycle model for somitogenesis: Mathematical formulation and numerical simulation

Autor: JR Collier, D. McInerney, S. Schnell, PK Maini, DJ Gavaghan, P. Houston, CD Stern

Publikováno v: Journal of theoretical biology. 207(3)

After many years of research, the mechanisms that generate a periodic pattern of repeated elements (somites) along the length of the embryonic body axis is still one of the major unresolved problems in developmental biology. Here we present a mathema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::b3a2dfab45e7d459212c02b4cc07d8b4
http://ora.ox.ac.uk/objects/uuid:5e26df71-cf05-4b72-99e0-8ecd84c82848

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Mathematical modelling of ethanol metabolism in normal subjects and chronic alcohol misusers

Autor: Gd, Smith, Lj, Shaw, Pk, Maini, Roberta J Ward, Tj, Peters, Jd, Murray

Publikováno v: Europe PubMed Central

The time course of ethanol disappearance from the blood has been examined in normal males and females and in alcohol misusers. Blood alcohol estimations were made over a period of 3 hr, following an oral dose of ethanol (0.8 g/kg body weight) adminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e67d7225959f6b6e01603835fe139263
http://europepmc.org/abstract/med/8471084

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Akademický článek

Scaling approaches and macroecology provide a foundation for assessing ecological resilience in the Anthropocene.

Autor: Enquist, Brian J., Erwin, Doug, Savage, Van, Marquet, Pablo A.

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences; 5/27/2024, Vol. 379 Issue 1902, p1-20, 20p

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