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Akademický článek

Gluteal Compartment Syndrome following Joint Arthroplasty under Epidural Anaesthesia: A Report of 4 Cases

Autor: V Kumar, K Saeed, A Panagopoulos, PJ Parker

Publikováno v: Journal of Orthopaedic Surgery, Vol 15 (2007)

Compartment syndrome is characterised by an increase in the interstitial pressure within a closed osseofascial compartment. This may be due to a decrease in compartment volume, an increase in compartment content or external pressures. We report 4 pat

Externí odkaz: https://doaj.org/article/8d767b02b2404882bec40ada39a9ba18

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Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion

Autor: Quétier I, Jj, Marshall, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Jt, Worrall, Baskaran P, Rajeeve V, Howell M, Aj, Copp, Stamp G, Rosewell I, Cutillas P, Holger Gerhardt, Pj, Parker, Aj, Cameron

Publikováno v: Cell Reports
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
Quétier, I, Marshall, J J T, Spencer-Dene, B, Lachmann, S, Casamassima, A, Franco, C, Escuin, S, Worrall, J T, Baskaran, P, Rajeeve, V, Howell, M, Copp, A J, Stamp, G, Rosewell, I, Cutillas, P, Gerhardt, H, Parker, P J & Cameron, A J M 2016, ' Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion ', Cell Reports, vol. 14, no. 3, pp. 440-448 . https://doi.org/10.1016/j.celrep.2015.12.049
Europe PubMed Central

Summary In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::27c8650d20abadd56d4df9fa631e90af

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The Treatment Role of the Plastic Nail Guard for Ingrowing Toenails

Autor: DG Robertson, PJ Parker

Publikováno v: Journal of the Royal Army Medical Corps. 147:183-186

An illustrative case of bilateral ingrowing toe-nails highlights the practical advantages of the use of the plastic nail guard (PNG). Insertion of the PNG is inexpensive and is easy to learn and perform. The technique is described and discussed. Its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e997cd9e7bb03c85585edb9a668fcc4
https://doi.org/10.1136/jramc-147-02-13

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Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C

Autor: Kj, Procyk, Rippo MR, Testi R, Hofmann F, Pj, Parker, Manuela Baccarini

Publikováno v: Europe PubMed Central

The activation of kinases of the mitogen-activated protein kinase superfamily initiated by lipopolysaccharide (LPS) plays an important role in transducing inflammatory signals. The pathway leading to the induction of stress-activated protein kinases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dfee5ad9d3929c156b6c614d7f1530b4
https://pubmed.ncbi.nlm.nih.gov/11001916

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Distinct mechanisms target stress and extracellular signal-activated kinase 1 and Jun N-terminal kinase during infection of macrophages with Salmonella

Autor: Kj, Procyk, Rippo MR, Testi R, Hoffmann F, Pj, Parker, Manuela Baccarini

Publikováno v: Europe PubMed Central

The interaction between bacteria and macrophages is central to the outcome of Salmonella infections. Salmonella can escape killing by these phagocytes and survive and multiply within them, giving rise to chronic infections. Cytokines produced by infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::71baf8be42acdd711733192c22a5032c
https://pubmed.ncbi.nlm.nih.gov/10528195

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Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

Autor: Julian Downward, Md, Waterfield, Pj, Parker

Publikováno v: Europe PubMed Central

The effect of autophosphorylation and protein kinase C-catalyzed phosphorylation on the tyrosine-protein kinase activity and ligand binding affinity of the epidermal growth factor (EGF) receptor has been studied. Kinetic parameters for the phosphoryl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::60020f902df758a0710dbe33990b8034
http://europepmc.org/abstract/med/2997213

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Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy

Autor: Marie Bogoyevitch, Pe, Glennon, Mb, Andersson, Clerk A, Lazou A, Cj, Marshall, Pj, Parker, Ph, Sugden

Publikováno v: Europe PubMed Central

Maximally effective concentrations of endothelin-1 (ET-1), acidic FGF (aFGF), or 12-O-tetradecanoylphorbol-13-acetate (TPA) activated mitogen-activated protein kinase (MAPK) by 3-4-fold in crude extracts of myocytes cultured from neonatal rat heart v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::218acf845244be85469ef2673f5c96b7
http://europepmc.org/abstract/med/7507104

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