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Akademický článek

A panel-based mutational signature of homologous recombination deficiency associates with response to PARP inhibition in metastatic castration-resistant prostate cancer.

Autor: Boiarsky D; Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA., Tewari AK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Gulhan DC; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA., Bakouny Z; Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, NY, New York, USA., Ananda G; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Savignano H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Lakshminarayanan G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., McClure HM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Silver R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Rosalind Franklin University of Medicine and Science, Chicago, Illinois, USA., Choueiri TK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Taplin ME; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA., Berchuck JE; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

Publikováno v: The Prostate [Prostate] 2024 Dec; Vol. 84 (16), pp. 1479-1489. Date of Electronic Publication: 2024 Sep 09.

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Akademický článek

Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes.

Autor: Maury EA; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.; Bioinformatics and Integrative Genomics Program and Harvard/MIT MD-PHD Program, Harvard Medical School, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jones A; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Seplyarskiy V; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Nguyen TTL; Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA., Rosenbluh C; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bae T; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wang Y; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Abyzov A; Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA., Khoshkhoo S; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA., Chahine Y; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhao S; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA., Venkatesh S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Root E; Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA., Voloudakis G; Center for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Roussos P; Center for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Akbarian S; Department of Psychiatry and Neuroscience, Friedman Brain Institute, Mount Sinai, New York, NY 10029, USA.; Department of Neuroscience, Friedman Brain Institute, Mount Sinai, New York, NY 10029, USA., Brennand K; Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA., Reilly S; Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA., Lee EA; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sunyaev SR; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Walsh CA; Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115, USA., Chess A; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Neuroscience, Friedman Brain Institute, Mount Sinai, New York, NY 10029, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. 217-224. Date of Electronic Publication: 2024 Oct 10.

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