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MODULATORY ROLE OF MONOMERIC AMYLOID BETA ON NEURONAL EXCITABILITY AND ITS IMPLICATIONS ON SYNAPTIC ACTIVITY OF IMMATURE CORTICAL NEURONS

Autor: PIZZI, ERIKA

So far the amyloid hypothesis has mainly driven the Alzheimer's Disease (AD) drugs development; however most of the anti A?-clinical trials have been suspended due to the lack of significant cognitive improvements as well as to the side effects cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f87a8abab060f253422927977cc8494

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The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β Oligomers.

Autor: Stravalaci, Matteo, Beeg, Marten, Rossi, Alessandro, Salmona, Mario, Diomede, Luisa, Gobbi, Marco, Tapella, Laura, Balducci, Claudia, Forloni, Gianluigi, Chiesa, Roberto, Biasini, Emiliano, Joshi, Pooja, Pizzi, Erika, Mazzanti, Michele

Publikováno v: Journal of Alzheimer's Disease; 2016, Vol. 54 Issue 3, p1485-1497, 13p, 8 Graphs

Synthesis and Characterization of Novel Mono- And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult

Autor: Giuseppe Pignataro, Anna Pannaccione, Lucio Annunziato, Antonio Vinciguerra, Erika Pizzi, Tiziana Petrozziello, Agnese Secondo, Stefania Ippati, Eloise Mastrangelo, Andrea Menegon, Pietro Randazzo, Stefano Barbini, Cecilia Caccavone, Mario Milani, Roselia Ciccone, Luca Muzio, Pierfausto Seneci, Davide Gornati, Eleonora Colombo, Amal Z. Hassan

Publikováno v: Journal of medicinal chemistry (Online) 64 (2021): 8333–8353. doi:10.1021/acs.jmedchem.1c00305
info:cnr-pdr/source/autori:Gornati D.; Ciccone R.; Vinciguerra A.; Ippati S.; Pannaccione A.; Petrozziello T.; Pizzi E.; Hassan A.; Colombo E.; Barbini S.; Milani M.; Caccavone C.; Randazzo P.; Muzio L.; Annunziato L.; Menegon A.; Secondo A.; Mastrangelo E.; Pignataro G.; Seneci P./titolo:Synthesis and Characterization of Novel Mono-And Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult/doi:10.1021%2Facs.jmedchem.1c00305/rivista:Journal of medicinal chemistry (Online)/anno:2021/pagina_da:8333/pagina_a:8353/intervallo_pagine:8333–8353/volume:64

Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca2+ ions, listed among putative targets in central nervous system (CNS) diseases in which a pH modification occurs. We targeted novel compounds able to modulate ASIC1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c20a7c07be1a20f4dc57376a9ac3f
http://www.cnr.it/prodotto/i/458062