Výsledky vyhledávání - "Piyali Guhathakurta"

Drug discovery for heart failure targeting myosin-binding protein C

Autor: Thomas A. Bunch, Piyali Guhathakurta, Andrew R. Thompson, Victoria C. Lepak, Anna L Carter, Jennifer J. Thomas, David D. Thomas, Brett A. Colson

Publikováno v: bioRxiv

Cardiac MyBP-C (cMyBP-C) interacts with actin-myosin to fine-tune cardiac muscle contractility. Phosphorylation of cMyBP-C, which reduces binding of cMyBP-C to actin or myosin, is often decreased in heart failure (HF) patients, and is cardioprotectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe953fb2475be7ad310949640d47046a
https://doi.org/10.1101/2023.04.03.535496

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Enhancing interaction of actin and actin-binding domain 1 of dystrophin with modulators: Toward improved gene therapy for Duchenne muscular dystrophy

Autor: Piyali Guhathakurta, Anna L. Carter, Andrew R. Thompson, Dillon Kurila, Jeffrey LaFrence, Li Zhang, Jake R. Trask, Bri Vanderheyden, Joseph M. Muretta, James M. Ervasti, David D. Thomas

Publikováno v: Journal of Biological Chemistry. 298:102675

Duchenne muscular dystrophy is a lethal muscle disease, caused by mutations in the gene encoding dystrophin, an actin-binding cytoskeletal protein. Absence of functional dystrophin results in muscle weakness and degeneration, eventually leading to ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1492b3313d87227e3159520649edb94
https://doi.org/10.1016/j.jbc.2022.102675

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High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

Autor: Thomas A. Bunch, Piyali Guhathakurta, Lepak Vc, Kanassatega R, Andrew R. Thompson, Brett A. Colson, Anna Wilson, David D. Thomas

Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac contractility. These interactions are regulated by cMyBP-C phosphorylation. Heart failure patients often have decreased cMyBP-C phosphorylation and phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89aefe73f4c490bc2e4c15bc6eb952c3
https://doi.org/10.1101/2021.03.24.436879

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Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen

Autor: Thomas A. Bunch, Piyali Guhathakurta, Andrew R. Thompson, Brett A. Colson, David D. Thomas, Victoria C. Lepak, Rhye Samuel Kanassatega, Anna Wilson

Publikováno v: The Journal of Biological Chemistry

Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by cMyBP-C phosphorylation. Heart failure patients often display decreased cMyBP-C phosphorylation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e8b63a383fc7d22dea35788b29aa60
https://pubmed.ncbi.nlm.nih.gov/34052227

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Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin

Autor: Robyn T. Rebbeck, Adam W. Avery, David D. Thomas, Anna K. Andrick, Bengt Svensson, Piyali Guhathakurta, Sarah A. Denha, Thomas S. Hays

Publikováno v: The Journal of Biological Chemistry

Numerous diseases are linked to mutations in the actin-binding domains (ABDs) of conserved cytoskeletal proteins, including β-III-spectrin, α-actinin, filamin, and dystrophin. A β-III-spectrin ABD mutation (L253P) linked to spinocerebellar ataxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd13ccfcd6f48ee724d62cab62765b5
https://pubmed.ncbi.nlm.nih.gov/33839680

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Actin-binding compounds, discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

Autor: Lien A. Phung, Anna Wilson, Piyali Guhathakurta, Sarah Lichtenberger, Ewa Prochniewicz, David D. Thomas

We have used spectroscopic and functional assays to evaluate the effects of a group of actin-binding compounds on striated muscle protein structure and function. Actin is present in every human cell, and its interaction with multiple myosin isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8ff1308e2c9d90636668138d830f0ab
https://doi.org/10.1101/2020.05.19.104257

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Actin-Binding Compounds, Discovered from Fret-Based High-Throughput Screening, Differentially Affect Skeletal and Cardiac Muscle

Autor: David D. Thomas, Piyali Guhathakurta, Lien A. Phung, Ewa Prochniewicz, Sarah Lichtenberger

Publikováno v: Biophysical Journal. 118:593a-594a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b03768d1577a233b590dfc2c3289c871
https://doi.org/10.1016/j.bpj.2019.11.3213

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