Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Pivaloyloxymethyl"'
Autor:
Shiku, Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato, Hiroshi
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10873
The benefits of CAR-T therapy could be expanded to the treatment of solid tumors through the use of derived autologous αβ T cell, but clinical trials of CAR-T therapy for patients with solid tumors have so far been disappointing. CAR-T therapy also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a56111fb73dd821c9b372afb4a3741aa
Akademický článek
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Akademický článek
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Publikováno v:
Journal of Medicinal Chemistry. 64:16703-16710
Intracellular phosphorylation of therapeutic nucleoside analogues into their active triphosphate metabolites is a prerequisite for their pharmacological activity. However, the initial phosphorylation of these unnatural nucleosides into their monophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b758b4c76a70df25cac257487ef898b
https://doi.org/10.1021/acs.jmedchem.1c01490
https://doi.org/10.1021/acs.jmedchem.1c01490
Autor:
Gabriel Birkus, Miroslav Smola, Petra Břehová, Lubomír Rulíšek, Martin Maxmilian Kaiser, Michal Šála, Aleš Marek, Martin Dračínský, Andrea Brázdová, Barbora Novotna, Zlatko Janeba, Milan Dejmek, Joshua R. Smith, Markéta Pimková Polidarová, Radim Nencka, Ondřej Páv, Evzen Boura, Ondrej Gutten
Publikováno v:
Journal of Medicinal Chemistry. 64:7596-7616
Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the activity of 3',3'-c-di(2'F,2'dAMP) and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583c7c8621ad313e02166230b7d6d0b2
https://doi.org/10.1021/acs.jmedchem.1c00301
https://doi.org/10.1021/acs.jmedchem.1c00301
Autor:
Marwa O. Mikati, Yasaman Barekatain, Damon M. Osbourn, Carey-Ann D. Burnham, Rachel L. Edwards, Victoria C. Yan, Cynthia S. Dowd, Florian L. Muller, Naomi Ghebremichael, Justin J. Miller, Kenneth M. Heidel, Audrey R. Odom John, Ishaan T. Shah
Publikováno v:
ACS Infect Dis
With the rising prevalence of multidrug-resistance, there is an urgent need to develop novel antibiotics. Many putative antibiotics demonstrate promising in vitro potency but fail in vivo due to poor drug-like qualities (e.g. serum half-life, oral ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da808b9eb618297e0a5c7d55b8690ea8
https://doi.org/10.1101/2020.07.23.214460
https://doi.org/10.1101/2020.07.23.214460
Autor:
Klaus Charisse, Christopher S. Theile, Ivan Zlatev, Jonathan O'Shea, Muthiah Manoharan, Rajat S. Das, Martin Maier, I. Ramesh Babu
Publikováno v:
Tetrahedron. 74:6182-6186
5′-(E)-Vinylphosphonate (VP) is an effective bioisostere of the natural 5′-monophosphate in small interfering RNAs (siRNAs). Solid-phase synthesis of VP-siRNAs requires the use of appropriately protected VP-phosphoramidites in combination with op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b538b6b6329491f1b8673066fb18f0
https://doi.org/10.1016/j.tet.2018.09.008
https://doi.org/10.1016/j.tet.2018.09.008
Autor:
David F. Wiemer, Nicholas A. Lentini, Andrew J. Wiemer, Michael M. Poe, Chia-Hung Christine Hsiao, Benjamin J. Foust
Publikováno v:
ACS Medicinal Chemistry Letters. 8:914-918
Studies of aryl phosphonate derivatives of a butyrophilin 3A1 ligand have resulted in identification of a potent stimulant of Vγ9 Vδ2 T cells. This compound, a mixed ester bearing one pivaloyloxymethyl substituent and one 1-naphthyl ester displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0914cc74c2c37dea9c3dcccc771e716
https://doi.org/10.1021/acsmedchemlett.7b00245
https://doi.org/10.1021/acsmedchemlett.7b00245
Publikováno v:
Organic Letters. 19:3624-3627
Commercially available 2′-O-pivaloyloxymethyl (PivOM) phosphoramidites were employed in an SPS protocol for RNA 5′ azides. The utility of the N3-RNAs in CuAAC and SPAAC was demonstrated by RNA 5′ labeling, chemical ligation including fragment j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4291c14de29aaf81ee4833f2de5c386
https://doi.org/10.1021/acs.orglett.7b01591
https://doi.org/10.1021/acs.orglett.7b01591
Autor:
David F. Wiemer, Xiaochen Lin, Rebekah R. Shippy, Michael M. Poe, Brendan M. Zangari, Olga Vinogradova, Sherry S Agabiti, Benjamin J. Foust, Jin Li, Andrew J. Wiemer, Chia-Hung Christine Hsiao
Publikováno v:
Journal of Medicinal Chemistry. 60:2373-2382
Butyrophilin 3A1 (BTN3A1) binds small phosphorous-containing molecules, which initiates transmembrane signaling and activates butyrophilin-responsive cells. We synthesized several phosphinophosphonates and their corresponding tris-pivaloyloxymethyl p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca1b02ba2251e4f6ed35c383464f72f
https://doi.org/10.1021/acs.jmedchem.6b00965
https://doi.org/10.1021/acs.jmedchem.6b00965