Zobrazeno 1 - 10
of 3 670
pro vyhledávání: '"Pitzalis, A."'
Using the Functional Renormalization Group approach we construct effective quantum spacetime geometries by self-consistently deforming the classical Schwarzschild-de Sitter black-hole solution. This involves studying how quantum corrections, driven b
Externí odkaz:
http://arxiv.org/abs/2410.16866
We present exact solutions for the cosmological embedding of a broad class of non-singular black holes, demonstrating that these objects exhibit an apparent horizon. The evolution of the latter is analyzed as a function of the cosmological redshift $
Externí odkaz:
http://arxiv.org/abs/2410.10459
We show that, in the framework of Einstein-scalar gravity, the de Sitter (dS) spacetime can be nucleated out of the anti de Sitter (AdS) one. This is done by using a scalar lump solution, which has an $\text{AdS}_4$ spacetime in the core, allows for
Externí odkaz:
http://arxiv.org/abs/2407.10469
We investigate the cosmological coupling of spherical, local astrophysical systems. We derive a general formula quantifying the cosmological coupling of the Misner-Sharp mass of these objects. We show that, in the weak-field limit, the cosmological c
Externí odkaz:
http://arxiv.org/abs/2406.06091
Motivated by the recent heated debate on whether the masses of local objects, such as compact stars or black holes (BHs), may be affected by the large-scale, cosmological dynamics, we analyze the conditions under which, in a general relativity framew
Externí odkaz:
http://arxiv.org/abs/2309.16444
Autor:
Gallagher-Syed, Amaya, Rossi, Luca, Rivellese, Felice, Pitzalis, Costantino, Lewis, Myles, Barnes, Michael, Slabaugh, Gregory
Whole Slide Images (WSIs) present a challenging computer vision task due to their gigapixel size and presence of numerous artefacts. Yet they are a valuable resource for patient diagnosis and stratification, often representing the gold standard for d
Externí odkaz:
http://arxiv.org/abs/2309.10650
Autor:
Gallagher-Syed, Amaya, Khan, Abbas, Rivellese, Felice, Pitzalis, Costantino, Lewis, Myles J., Slabaugh, Gregory, Barnes, Michael R.
Rheumatoid Arthritis (RA) is a chronic, autoimmune disease which primarily affects the joint's synovial tissue. It is a highly heterogeneous disease, with wide cellular and molecular variability observed in synovial tissues. Over the last two decades
Externí odkaz:
http://arxiv.org/abs/2309.07255
Autor:
Piero Ruscitti, Damiano Currado, Felice Rivellese, Marta Vomero, Luca Navarini, Paola Cipriani, Costantino Pitzalis, Roberto Giacomelli
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Objective Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationship to the ubiquitin–
Externí odkaz:
https://doaj.org/article/75194bde7dd246e9b0525addd9e6fd14
Publikováno v:
JCAP 11 (2023), 007
We show that -- in the framework of general relativity (GR) -- if black holes (BHs) are singularity-free objects, they couple to the large-scale cosmological dynamics. We find that the leading contribution to the resulting growth of the BH mass ($M_{
Externí odkaz:
http://arxiv.org/abs/2306.11588
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023