Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons

Autor: Anne Vassalli, Sha Li, Rosalind M. John, Francesca Amati, Ali Seifinejad, Yoan Arribat, Bridget Allen, Mehdi Tafti, Sylvain Pradervand, Hassan Pezeshgi Modarres, Cyril Mikhail

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 34, pp. 17061-17070

Significance Hypocretin (HCRT) and melanin concentrating hormone are brain neuropeptides involved in multiple functions, including sleep and metabolism. Loss of HCRT causes the sleep disorder narcolepsy. To understand how these neuropeptides are prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c50fc2c0893871645077dd1b5bfee7d
https://orca.cardiff.ac.uk/id/eprint/124737/1/1902148116.full.pdf

The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization

Autor: Benoît Saint-Mleux, Michel Muhlethaler, Laurence Bayer, Barbara E. Jones, Danièle Machard, Laurent Bernheim, Mauro Serafin, Emmanuel Eggermann

Publikováno v: Journal of Neuroscience, Vol. 23, No 5 (2003) pp. 1557-1562

Wakefulness depends on the activity of hypocretin–orexin neurons because their lesion results in narcolepsy. How these neurons maintain their activity to promote wakefulness is not known. Here, by recording for the first time from hypocretin–orex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5bb1748714de6600dcb6cb267b162c
https://archive-ouverte.unige.ch/unige:10241