Preclinical Activity of the Rational Combination of Selumetinib (AZD6244) in Combination with Vorinostat in KRAS-Mutant Colorectal Cancer Models

Autor: Morelli MP, Tentler JJ, Kulikowski GN, Tan AC, Bradshaw Pierce EL, Pitts TM, Brown AM, Nallapareddy S, Arcaroli JJ, Serkova NJ, Hidalgo M, Eckhardt S.G., CIARDIELLO, Fortunato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::790725d48d8c3be930585bb62d36c041
http://hdl.handle.net/11591/190011

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Expanding the landscape of oncogenic drivers and treatment options in acral and mucosal melanomas by targeted genomic profiling.

Autor: Turner JA; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Van Gulick RJ; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Robinson WA; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Mughal T; Division of Hematology-Oncology, Tufts University Cancer Center, Boston, Massachusetts, USA., Tobin RP; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., MacBeth ML; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Holman B; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Classon A; Foundation Medicine Inc., Cambridge, Massachusetts, USA., Bagby SM; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Yacob BW; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Hartman SJ; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Silverman I; Ignyta, Inc., San Diego, California, USA., Vorwald VM; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Gorden N; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Gonzalez R; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Gay LM; Foundation Medicine Inc., Cambridge, Massachusetts, USA., Ali SM; Foundation Medicine Inc., Cambridge, Massachusetts, USA., Benson A; Foundation Medicine Inc., Cambridge, Massachusetts, USA., Miller VA; Foundation Medicine Inc., Cambridge, Massachusetts, USA., Ross JS; Foundation Medicine Inc., Cambridge, Massachusetts, USA.; Department of Pathology, Upstate Medical University, Syracuse, New York, USA., Pitts TM; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Rioth MJ; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Lewis KD; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Medina T; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., McCarter MD; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Gonzalez R; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Couts KL; Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.; Center for Rare Melanomas, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Publikováno v: International journal of cancer [Int J Cancer] 2024 Nov 15; Vol. 155 (10), pp. 1792-1807. Date of Electronic Publication: 2024 Jul 12.

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer.

Autor: Ivancevic A; BioFrontiers Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Simpson DM; BioFrontiers Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Joyner OM; BioFrontiers Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Bagby SM; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Nguyen LL; BioFrontiers Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA., Bitler BG; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO, USA., Pitts TM; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Chuong EB; BioFrontiers Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA.

Publikováno v: Science advances [Sci Adv] 2024 Jul 19; Vol. 10 (29), pp. eado1218. Date of Electronic Publication: 2024 Jul 17.