Neurofilament Light Chain in Aqueous Humor as a Marker of Neurodegeneration in Glaucoma

Autor: Lin JB, Pitts KM, El Helwe H, Neeson C, Hall NE, Falah H, Schultz SA, Wang SL, Lo K, Song C, Margeta MA, Solá-Del Valle D

Publikováno v: Clinical Ophthalmology, Vol Volume 17, Pp 2209-2217 (2023)

Jonathan B Lin,1 Kristen M Pitts,1 Hani El Helwe,1 Cameron Neeson,1 Nathan E Hall,1 Henisk Falah,1 Stephanie A Schultz,2 Silas L Wang,1 Kristine Lo,1 Christian Song,1 Milica A Margeta,1,* David Solá-Del Valle1,* 1Department of Ophthalmology,

Externí odkaz: https://doaj.org/article/531febb6a44443719cfe5b5be3feb571

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An implantable device for wireless monitoring of diverse physio-behavioral characteristics in freely behaving small animals and interacting groups.

Autor: Ouyang W; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA., Kilner KJ; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA., Xavier RMP; NeuroLux Inc., Northfield, IL 60093, USA., Liu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Lu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Feller SM; NeuroLux Inc., Northfield, IL 60093, USA., Pitts KM; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA., Wu M; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Ausra J; NeuroLux Inc., Northfield, IL 60093, USA., Jones I; NeuroLux Inc., Northfield, IL 60093, USA., Wu Y; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Luan H; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Trueb J; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA., Higbee-Dempsey EM; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Stepien I; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Ghoreishi-Haack N; Developmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA., Haney CR; Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA., Li H; Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA., Kozorovitskiy Y; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA., Heshmati M; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA; Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195, USA., Banks AR; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA., Golden SA; Department of Biological Structure, University of Washington, Seattle, WA 98195, USA; Center of Excellence in Neurobiology of Addiction, Pain, and Emotion (NAPE), University of Washington, Seattle, WA 98195, USA. Electronic address: sagolden@uw.edu., Good CH; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; NeuroLux Inc., Northfield, IL 60093, USA. Electronic address: cameron.good@northwestern.edu., Rogers JA; Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Chemistry, Northwestern University, Evanston, IL 60208, USA; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA. Electronic address: jrogers@northwestern.edu.

Publikováno v: Neuron [Neuron] 2024 Jun 05; Vol. 112 (11), pp. 1764-1777.e5. Date of Electronic Publication: 2024 Mar 26.

APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.

Autor: Yin Z; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Rosenzweig N; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kleemann KL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; School of Computing, University of Portsmouth, Portsmouth, UK., Zhang X; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Brandão W; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Margeta MA; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Schroeder C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sivanathan KN; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Silveira S; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gauthier C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Mallah D; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Pitts KM; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Durao A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Herron S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA., Shorey H; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cheng Y; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Barry JL; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Krishnan RK; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wakelin S; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rhee J; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Yung A; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Aronchik M; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wang C; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.; Institute for Brain Science and Disease, Chongqing Medical University, Chongqing, China., Jain N; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Bao X; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Gerrits E; Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Brouwer N; Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tenen DG; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.; Cancer Science Institute, National University of Singapore, Singapore, Singapore., Ikezu T; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA., Santander NG; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Instituto de Ciencias de la Salud, Universidad de O´Higgins, Rancagua, Chile., McKinsey GL; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Baufeld C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sheppard D; Department of Medicine, Cardiovascular Research Center, University of California, San Francisco, San Francisco, CA, USA., Krasemann S; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf UKE, Hamburg, Germany., Nowarski R; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Eggen BJL; Department of Biomedical Sciences of Cells & Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Clish C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tanzi RE; Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA, USA., Madore C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Laboratoire NutriNeuro, UMR1286, INRAE, Bordeaux INP, University of Bordeaux, Bordeaux, France., Arnold TD; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Butovsky O; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. obutovsky@bwh.harvard.edu.; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. obutovsky@bwh.harvard.edu.

Publikováno v: Nature immunology [Nat Immunol] 2023 Nov; Vol. 24 (11), pp. 1839-1853. Date of Electronic Publication: 2023 Sep 25.