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Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors.

Autor: Palmer JT; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia. Electronic address: j.palmer@biota.com.au., Axford LC; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Barker S; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Bennett JM; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Blair M; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Collins I; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Davies DT; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Ford L; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Gannon CT; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Lancett P; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Logan A; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Lunniss CJ; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Morton CJ; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Offermann DA; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Pitt GR; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Rao BN; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Singh AK; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Shukla T; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Srivastava A; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Stokes NR; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Thomaides-Brears HB; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Yadav A; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Haydon DJ; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Sep 01; Vol. 24 (17), pp. 4215-22. Date of Electronic Publication: 2014 Jul 19.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Autor: Axford LC; Biota Holdings Ltd, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia. Electronic address: l.offermann@biota.com.au., Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Dec 15; Vol. 23 (24), pp. 6598-603. Date of Electronic Publication: 2013 Nov 04.

Non-peptide oxytocin agonists.

Autor: Pitt GR; Ferring Research Ltd, Chilworth Science Park, Southampton SO16 7NP, UK., Batt AR, Haigh RM, Penson AM, Robson PA, Rooker DP, Tartar AL, Trim JE, Yea CM, Roe MB

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Sep 06; Vol. 14 (17), pp. 4585-9.

Synthetic inhibitors of human tissue kallikrein.

Autor: Evans DM; Ferring Research Institute, University of Southampton Research Centre, UK., Jones DM, Pitt GR, Ashworth D, De Clerck F, Verheyen F, Szelke M

Publikováno v: Immunopharmacology [Immunopharmacology] 1996 May; Vol. 32 (1-3), pp. 117-8.