Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pitchumani Sivakumar"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH) are major metabolic diseases with increasing global prevalence and no approved therapies. There is a mounting need to develop biomarkers of diagnosis, prognos
Externí odkaz:
https://doaj.org/article/fb07a9764b384ae8acefbeb77134fef9
Autor:
Pitchumani Sivakumar, Ron Ammar, John Ryan Thompson, Yi Luo, Denis Streltsov, Mary Porteous, Carly McCoubrey, Edward Cantu, Michael F. Beers, Gabor Jarai, Jason D. Christie
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant unmet medical need. Development of transformational therapies for IPF is challenging in part to due to lack of robust predictive biomarkers of prognosi
Externí odkaz:
https://doaj.org/article/e669f581a774421099ad94ddbc23a0a9
Autor:
Pitchumani Sivakumar, John Ryan Thompson, Ron Ammar, Mary Porteous, Carly McCoubrey, Edward Cantu, Kandasamy Ravi, Yan Zhang, Yi Luo, Denis Streltsov, Michael F. Beers, Gabor Jarai, Jason D. Christie
Publikováno v:
ERJ Open Research, Vol 5, Iss 3 (2019)
Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of lung function, remains a fatal disease with a significant unmet medical need. Patients with severe IPF often develop acute exacerbations resulting in the ra
Externí odkaz:
https://doaj.org/article/6fd6b7966811448c83dc2ff77e664ba7
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215565 (2019)
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease affecting ~5 million people globally. We have constructed an accurate model of IPF disease status using elastic net regularized regression on clinical gene expression data.
Externí odkaz:
https://doaj.org/article/3d0c7a16105e4be4a11485f11e78bf2e
Autor:
Yi Luo, Denis Streltsov, Mary K. Porteous, Carly McCoubrey, Pitchumani Sivakumar, Edward Cantu, Jason D. Christie, Gabor Jarai, John Ryan Thompson, Michael F. Beers, Ron Ammar
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Respiratory Research
Respiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a significant unmet medical need. Development of transformational therapies for IPF is challenging in part to due to lack of robust predictive biomarkers of prognosis and tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9608672ed91ae810fbf18a50b068e370
https://doi.org/10.1186/s12931-021-01860-3
https://doi.org/10.1186/s12931-021-01860-3
Autor:
John Ryan Thompson, Jason D. Christie, Yi Luo, Mary K. Porteous, Carly McCoubrey, Pitchumani Sivakumar, Edward Cantu, Gabor Jarai, Kandasamy Ravi, Michael F. Beers, Denis Streltsov, Yan Zhang, Ron Ammar
Publikováno v:
ERJ Open Research, Vol 5, Iss 3 (2019)
ERJ Open Research
ERJ Open Research
Idiopathic pulmonary fibrosis (IPF), the scarring of lung parenchyma resulting in the loss of lung function, remains a fatal disease with a significant unmet medical need. Patients with severe IPF often develop acute exacerbations resulting in the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05781828fc3ace8632a686069d638ba7
http://openres.ersjournals.com/content/5/3/00117-2019.full
http://openres.ersjournals.com/content/5/3/00117-2019.full
Publikováno v:
Connective tissue research. 60(1)
An imbalance of extracellular matrix (ECM) deposition and turnover is a hallmark of fibrotic pathologies as opposed to normal repair response to injury across several organs. Antifibrotic approaches to date have targeted multiple mechanisms and pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38237595aa44729b6d0811d5c216df15
https://pubmed.ncbi.nlm.nih.gov/30071759
https://pubmed.ncbi.nlm.nih.gov/30071759
Publikováno v:
Current Opinion in Pulmonary Medicine. 18:462-469
This review describes the challenges created by the existence of multiple molecular pathways leading to fibrosis and proposes that attention be focused on targeting the fibroblasts and myofibroblasts which themselves produce multiple cytokines and gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62663e29a7a0a74215281a76672f176e
https://doi.org/10.1097/mcp.0b013e328356800f
https://doi.org/10.1097/mcp.0b013e328356800f
Autor:
Pitchumani Sivakumar, Donna M. Peters, Sarah L. Dallas, Cay M. Kielty, Deane F. Mosher, Qian Chen, Martin J. Humphries, Carolyn J.P. Jones
Publikováno v:
Journal of Biological Chemistry. 280:18871-18880
Latent transforming growth factor-beta-binding proteins (LTBPs) are extracellular matrix (ECM) glycoproteins that play a major role in the storage of latent TGF beta in the ECM and regulate its availability. Here we show that fibronectin is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68beccbe198f0106cfe3cbf955271e40
https://doi.org/10.1074/jbc.m410762200
https://doi.org/10.1074/jbc.m410762200
Autor:
Pitchumani Sivakumar, Di Chen, Lynda F. Bonewald, Jian Q. Feng, Ling Ye, Haiyang Huang, Tetsuo Kunieda, Sarah L. Dallas, Yuji Mishina, Adele L. Boskey, Takeo W. Tsutsui, Mark Dallas
Publikováno v:
Journal of Biological Chemistry. 280:6197-6203
Understanding the molecular mechanisms by which cartilage formation is regulated is essential toward understanding the physiology of both embryonic bone development and postnatal bone growth. Although much is known about growth factor signaling in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fa11af6a8161bc7e5c03926c620f59
https://doi.org/10.1074/jbc.m412911200
https://doi.org/10.1074/jbc.m412911200