B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during aging.

Autor: Carey A; Molecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Pitcher LE; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Jang IH; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Nguyen K; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Cholensky S; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Robbins PD; Molecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA., Camell CD; Molecular Pharmacology and Therapeutics Graduate Program, Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota, 55455, USA.; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, 55455, USA.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics.

Autor: Zhang L; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Pitcher LE; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Prahalad V; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Niedernhofer LJ; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA., Robbins PD; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.

Publikováno v: The FEBS journal [FEBS J] 2023 Mar; Vol. 290 (5), pp. 1362-1383. Date of Electronic Publication: 2022 Feb 01.

Cellular senescence: a key therapeutic target in aging and diseases.

Autor: Zhang L; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Pitcher LE; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Yousefzadeh MJ; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Robbins PD; Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Zhu Y; Robert and Arlene Kogod Center on Aging, and.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Aug 01; Vol. 132 (15).

Targeting ATM to mitigate intervertebral disc degeneration.

Autor: Pitcher LE; Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Wong AK; Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

Publikováno v: Aging [Aging (Albany NY)] 2021 Apr 22; Vol. 13 (8), pp. 10814-10815. Date of Electronic Publication: 2021 Apr 22.