Repair of joint damage in patients with rheumatoid arthritis does not relate to previous suppression of inflammation: a subanalysis after 8 years treat-to-target in the BeSt-trial

Autor: Cornelia F Allaart, Tom W J Huizinga, Linda Dirven, Willem F Lems, Pit J S M Kerstens, Marianne van den Broek, Gülşah Akdemir, Iris M Markusse, Joy Ardjuna van der Pol

Publikováno v: RMD Open, Vol 9, Iss 2 (2023)

Objectives To investigate whether repair of erosions and joint space narrowing (JSN) in rheumatoid arthritis (RA) occurs and whether clinical variables predict this.Methods Eight-year follow-up data of the BeSt-study were used. Patients with recent o

Externí odkaz: https://doaj.org/article/2d566000d38d4551865c743491846a7b

Favourable effect of a 'second hit' after 13 weeks in early RA non-responders: the Amsterdam COBRA treat-to-target randomized trial

Autor: Linda Hartman, Linda A Rasch, Samina A Turk, Marieke M ter Wee, Pit J S M Kerstens, Conny J van der Laken, Michael T Nurmohamed, Dirkjan van Schaardenburg, Lilian H D van Tuyl, Alexandre E Voskuyl, Maarten Boers, Willem F Lems

Publikováno v: Rheumatology (Oxford, England), 62(6), 2098-2105. Oxford University Press
Hartman, L, Rasch, L A, Turk, S A, ter Wee, M M, Kerstens, P J S M, van der Laken, C J, Nurmohamed, M T, van Schaardenburg, D, van Tuyl, L H D, Voskuyl, A E, Boers, M & Lems, W F 2023, ' Favourable effect of a 'second hit' after 13 weeks in early RA non-responders : the Amsterdam COBRA treat-to-target randomized trial ', Rheumatology (Oxford, England), vol. 62, no. 6, pp. 2098-2105 . https://doi.org/10.1093/rheumatology/keac582, https://doi.org/10.1093/rheumatology/keac582

Objective The aim of this study was to investigate the effect of treat-to-target combination therapy with intensification at 13 weeks in early RA. Methods Early RA patients were classified as being at high or low risk of worsening RA based on disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b279aed501a84b72c56f06168d21844
https://research.vumc.nl/en/publications/f6f86ced-4bc5-4986-9940-8edebc439842

Long-term effects on bone mineral density after four years of treatment with two intensive combination strategies, including initially high-dose prednisolone, in early rheumatoid arthritis patients: the COBRA-light trial

Autor: Willem F. Lems, Irene E. M. Bultink, Pit J S M Kerstens, M. T. Nurmohamed, D. den Uyl, D. van Schaardenburg, Alexandre E. Voskuyl, Maarten Boers, N. P. C. Konijn, M. M. ter Wee, M. J. J. Lucassen

Publikováno v: Lucassen, M J J, ter Wee, M, den Uyl, D, Konijn, NPC, Nurmohamed, MT, Voskuyl, AE, van Schaardenburg, D, Kerstens, P J S M, Bultink, IEM, Boers, M & Lems, WF 2021, ' Long-term effects on bone mineral density after four years of treatment with two intensive combination strategies, including initially high-dose prednisolone, in early rheumatoid arthritis patients: the COBRA-light trial ', Osteoporosis International, vol. 32, no. 7, 10.1007/s00198-020-05781-7, pp. 1441-1449 . https://doi.org/10.1007/s00198-020-05781-7
Osteoporosis International
Osteoporosis international, 32(7), 1441-1449. Springer London
Osteoporosis International, 32(7):10.1007/s00198-020-05781-7, 1441-1449. Springer London

Summary In this study, no difference in bone loss was observed between patients with early RA initially treated with COmbinatietherapie Bij Reumatoide Artritis (COBRA) (including initially 60 mg/day prednisolone) and patients treated with COBRA-light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0a3c21f72884df3ebc9379b3d50c23
https://research.vumc.nl/en/publications/8acfa484-881d-45a4-ba29-968ff56614bd

Do Short and Sustained Periods of American College of Rheumatology/European League Against Rheumatism Remission Predict Functional and Radiographic Outcome in Early Rheumatoid Arthritis Patients With Low Overall Damage Progression?

Autor: Alexandre E. Voskuyl, Lilian H D van Tuyl, N. Konijn, Marieke M. ter Wee, Willem F. Lems, Pit J S M Kerstens, Debby den Uyl, Michael T. Nurmohamed, Dirkjan van Schaardenburg, Maarten Boers

Publikováno v: Arthritis care & research, 69(7), 989-996. John Wiley and Sons Inc.

To investigate whether remission at single and consecutive visits predicts good outcome in early rheumatoid arthritis (RA). The presence of remission according to American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ded634c67dfbf88968b46d7680c2832
https://doi.org/10.1002/acr.23112

Evaluating Adherence to a Treat-to-Target Protocol in Recent-Onset Rheumatoid Arthritis: Reasons for Compliance and Hesitation

Autor: I.M. Markusse, Pit J S M Kerstens, Linda Dirven, Twj Huizinga, Cornelia F Allaart, H.K. Ronday, P. B. J. de Sonnaville, W.F. Lems, K.H. Han

Publikováno v: Arthritis Care and Research

Objective To evaluate rheumatologists' adherence to a low Disease Activity Score (DAS)-steered treat-to-target (T2T) strategy in treatment of patients with rheumatoid arthritis (RA) and to assess associated conditions. Methods Data of the BeSt study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05ab5fb17896cbb05469851437bcd22f
https://doi.org/10.1002/acr.22681