Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pishan Chang"'
Autor:
Phillip M. Muza, Daniel Bush, Marta Pérez-González, Ines Zouhair, Karen Cleverley, Miriam L. Sopena, Rifdat Aoidi, Steven J. West, Mark Good, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher, Pishan Chang
Publikováno v:
iScience, Vol 26, Iss 2, Pp 106073- (2023)
Summary: The Dp(10)2Yey mouse carries a ∼2.3-Mb intra-chromosomal duplication of mouse chromosome 10 (Mmu10) that has homology to human chromosome 21, making it an essential model for aspects of Down syndrome (DS, trisomy 21). In this study, we inv
Externí odkaz:
https://doaj.org/article/3fbb7b3045ba4d09b1a49b9bef3ec9e9
Autor:
Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Nathanael Shing, Suzanna Noy, Frances K. Wiseman, Neil Burgess, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth M.C. Fisher
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary: Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associ
Externí odkaz:
https://doaj.org/article/0726a09e79f942f28afb7ca0608d677c
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 296-306 (2014)
Phosphatidylinositol (3–5) trisphosphate (PIP3) is a central regulator of diverse neuronal functions that are critical for seizure progression, however its role in seizures is unclear. We have recently hypothesised that valproic acid (VPA), one of
Externí odkaz:
https://doaj.org/article/196ddb53fd9140ec8c1fcedcf2ed6045
Autor:
Pishan Chang, Benoit Orabi, Rania M. Deranieh, Manik Dham, Oliver Hoeller, Jakob A. Shimshoni, Boris Yagen, Meir Bialer, Miriam L. Greenberg, Matthew C. Walker, Robin S. B. Williams
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 1, Pp 115-124 (2012)
SUMMARY Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple
Externí odkaz:
https://doaj.org/article/d203726140b3427493440a80b9c53ea0
Publikováno v:
Neurobiology of learning and memory. 195
The hippocampus (HPC) and medial prefrontal cortex (mPFC) have well-established roles in cognition, emotion, and sensory processing. In recent years, interests have shifted towards developing a deeper understanding of the mechanisms underlying intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a14f2f33d8d92cf1b27dc17af95fa3c
https://pubmed.ncbi.nlm.nih.gov/36174886
https://pubmed.ncbi.nlm.nih.gov/36174886
Publikováno v:
J Neurosci
Early life pain experience (ELP) alters adult pain behaviour and increases injury induced pain hypersensitivity, but the effect of ELP upon adult functional brain connectivity is not known. We have performed continuous local field potential (LFP) rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb98be2bc726892a36a9a12c38d27272
https://pubmed.ncbi.nlm.nih.gov/36192150
https://pubmed.ncbi.nlm.nih.gov/36192150
Autor:
Phillip Muza, Daniel Bush, Marta Pérez-González, Ines Zouhair, Karen Cleverley, Miriam Llorian Sopena, Rifdat Aoidi, Steven J. West, Mark Good, Victor L.J. Tybulewicz, Matthew C. Walker, Elizabeth MC Fisher, Pishan Chang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c3206ba2085dc7ed16e0d3fd2154027
https://doi.org/10.2139/ssrn.4266339
https://doi.org/10.2139/ssrn.4266339
Publikováno v:
eNeuro
When skin afferents are activated, the sensory signals are transmitted to the spinal cord and eventually reach the primary somatosensory cortex (SI), initiating the encoding of the sensory percept in the brain. While subsets of primary afferents medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96ea27cd8d6d3ddc3e348758dea0ab4
https://pubmed.ncbi.nlm.nih.gov/32759177
https://pubmed.ncbi.nlm.nih.gov/32759177
Autor:
Elizabeth M. C. Fisher, Suzanna Noy, Nathanael Shing, Stephanie Schorge, Daniel Bush, Victor L. J. Tybulewicz, Neil Burgess, Tara Canonica, Frances K. Wiseman, Mark Andrew Good, Pishan Chang, Matthew C. Walker
Publikováno v:
1163.e4
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Cell Reports
Cell Reports, Vol 30, Iss 4, Pp 1152-1163.e4 (2020)
Summary Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5e6699f0a3da2804dd4e465cb08d89
http://hdl.handle.net/10044/1/76727
http://hdl.handle.net/10044/1/76727
Publikováno v:
Neuroscience. 338:207-219
This review addresses the fundamental question of how we first experience pain, at the beginning of our lives. The brain is activated by peripheral tissue damaging stimulation from birth, but unlike other sensory systems, the pain system in healthy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a028cd44bbcabfb7bf9a91f51f78a05
https://doi.org/10.1016/j.neuroscience.2016.07.026
https://doi.org/10.1016/j.neuroscience.2016.07.026