Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Piruthivi Sukumar"'
Autor:
Helen Imrie, Hema Viswambharan, Natalie J Haywood, Katherine I Bridge, Nadira Y Yuldasheva, Stacey Galloway, Katie J Simmons, Richard M Cubbon, Piruthivi Sukumar, Nicole T Watt, Laeticia Lichtenstein, Judy I Wyatt, Hiromi Kudo, Robert Goldin, Baptiste Rode, Stephen B Wheatcroft, Mark T Kearney
Publikováno v:
Adipocyte, Vol 11, Iss 1, Pp 366-378 (2022)
High fat diet (HFD)-induced obesity leads to perturbation in the storage function of white adipose tissue (WAT) resulting in deposition of lipids in tissues ill-equipped to deal with this challenge. The role of insulin like growth factor-1 (IGF-1) in
Externí odkaz:
https://doaj.org/article/3a306229dac84d0493dc86af288e28b8
Autor:
Sujith Kumar Pulukool, Sai Krishna Srimadh Bhagavatham, Vishnu Kannan, Piruthivi Sukumar, Rajesh Babu Dandamudi, Shamika Ghaisas, Haripriya Kunchala, Darshan Saieesh, Ashwin Ashok Naik, Ashish Pargaonkar, Anuj Sharma, Venketesh Sivaramakrishnan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks of POAG. We analyzed clinical data, cyto
Externí odkaz:
https://doaj.org/article/7c8d5e80c6984f2a9a441ababc5e7595
Autor:
Faye L. Styles, Moza M. Al-Owais, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Nishani T. Hettiarachchi, Jonathan D. Lippiat, Aisling Minard, Robin S. Bon, Karen Porter, Piruthivi Sukumar, Chris Peers, Lee D. Roberts
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation.
Externí odkaz:
https://doaj.org/article/de761f22f16e420bb481b26f474f0f11
Autor:
Sujith Kumar Pulukool, Sai Krishna Srimadh Bhagavatham, Vishnu Kannan, Piruthivi Sukumar, Rajesh Babu Dandamudi, Shamika Ghaisas, Haripriya Kunchala, Darshan Saieesh, Ashwin Ashok Naik, Ashish Pargaonkar, Anuj Sharma, Venketesh Sivaramakrishnan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/a50f4064f07144e18044733451efaea6
Autor:
Fiona Bartoli, Marjolaine Debant, Eulashini Chuntharpursat-Bon, Elizabeth L. Evans, Katie E. Musialowski, Gregory Parsonage, Lara C. Morley, T. Simon Futers, Piruthivi Sukumar, T. Scott Bowen, Mark T. Kearney, Laeticia Lichtenstein, Lee D. Roberts, David J. Beech
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 i
Externí odkaz:
https://doaj.org/article/7a5506da60ec4fa4ab0afb685437f3d2
Autor:
Talia Caspi, Sam Straw, Chew Cheng, Jack O Garnham, Jason L. Scragg, Jessica Smith, Aaron O. Koshy, Eylem Levelt, Piruthivi Sukumar, John Gierula, David J. Beech, Mark T. Kearney, Richard M. Cubbon, Stephen B. Wheatcroft, Klaus K. Witte, Lee D. Roberts, T. Scott Bowen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 18 (2020)
Background People with chronic heart failure (CHF) experience severe skeletal muscle dysfunction, characterized by mitochondrial abnormalities, which exacerbates the primary symptom of exercise intolerance. However, the molecular triggers and charact
Externí odkaz:
https://doaj.org/article/77f1fe2c40ff4e25b5657d33ba7106ee
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
Autor:
Harsha Bhattacharjee, Kasturi Bhattacharjee, Dipankar Das, Manpreet Singh, Piruthivi Sukumar, Diva Kant Misra
Publikováno v:
Indian Journal of Ophthalmology, Vol 65, Iss 10, Pp 949-954 (2017)
Purpose: Our study aims to evaluate the morphology, histopathology, and immunohistochemistry of the spontaneously late dislocated capsular bag-intraocular lens (CB-IOL) complex. Various etiologies and possible pathogenesis of the event are also discu
Externí odkaz:
https://doaj.org/article/604f9bd77b1c41f7966612723e2e74fc
Autor:
Sai Krishna Srimadh Bhagavatham, Anuj Kumar Sharma, Darshan Saieesh, Rajesh Babu Dandamudi, Venketesh Sivaramakrishnan, Haripriya Kunchala, Ashish Pargaonkar, Piruthivi Sukumar, Ashwin Ashok Naik, Shamika Ghaisas, Vishnu Kannan, Sujith Kumar Pulukool
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports
Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks of POAG. We analyzed clinical data, cytokine prof
Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC channels are thought to act as complex integrators of physical and chemical environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c68b1f75dcb1d393f4f60d83b95c600