Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Pirow, Bekker"'
Autor:
Peter A. Merkel, John Niles, Richard Jimenez, Robert F. Spiera, Brad H. Rovin, Andrew Bomback, Christian Pagnoux, Antonia Potarca, Thomas J. Schall, Pirow Bekker, for the CLASSIC Investigators
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 11, Pp 662-671 (2020)
Objective This study aimed to evaluate the safety of avacopan, an orally administered C5a receptor inhibitor, for the treatment of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis in addition to standard‐of‐care (SOC) treatment
Externí odkaz:
https://doaj.org/article/bb81072b122a4bb88073ca8840742823
Autor:
Naomi J Patel, David R W Jayne, Peter A Merkel, Pirow Bekker, Yuqing Zhang, Huibin Yue, John H Stone
Publikováno v:
The Lancet Rheumatology. 5:e130-e138
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86d21af0b7442dc2dc2ce14d0973e04
https://doi.org/10.1016/s2665-9913(23)00030-9
https://doi.org/10.1016/s2665-9913(23)00030-9
Autor:
Pirow Bekker, Daniel Dairaghi, Lisa Seitz, Manmohan Leleti, Yu Wang, Linda Ertl, Trageen Baumgart, Sarah Shugarts, Lisa Lohr, Ton Dang, Shichang Miao, Yibin Zeng, Pingchen Fan, Penglie Zhang, Daniel Johnson, Jay Powers, Juan Jaen, Israel Charo, Thomas J Schall
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210593 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0164646.].
Externí odkaz:
https://doaj.org/article/a84a81f1520c4d6e9e34354e7c569191
Autor:
Michael George, Andreas Kronbichler, Christian Pagnoux, Jason Springer, Kerstin W.A. Westman, Huibin Yue, Pirow Bekker, Emil Degoma, David Jayne, Peter Merkel
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS Standard therapy for ANCA-associated vasculitis (AAV) includes glucocorticoids (GC), which are associated with increased infections. Avacopan is an orally administered selective inhibitor of the C5a receptor recently approved for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a9a2e04a37bd46cfb6e2bfa45dcf416
https://doi.org/10.1093/ndt/gfac109.001
https://doi.org/10.1093/ndt/gfac109.001
Autor:
Pirow Bekker, Daniel Dairaghi, Lisa Seitz, Manmohan Leleti, Yu Wang, Linda Ertl, Trageen Baumgart, Sarah Shugarts, Lisa Lohr, Ton Dang, Shichang Miao, Yibin Zeng, Pingchen Fan, Penglie Zhang, Daniel Johnson, Jay Powers, Juan Jaen, Israel Charo, Thomas J Schall
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164646 (2016)
The complement 5a receptor has been an attractive therapeutic target for many autoimmune and inflammatory disorders. However, development of a selective and potent C5aR antagonist has been challenging. Here we describe the characterization of CCX168
Externí odkaz:
https://doaj.org/article/cc8d52d98d57413ea3878ceea94d7d27
Autor:
Thomas J. Schall, Pirow Bekker, Classic Investigators, Andrew S. Bomback, Brad H. Rovin, Christian Pagnoux, John L. Niles, Robert Spiera, Antonia Potarca, Peter A. Merkel, Richard A.H. Jimenez
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 11, Pp 662-671 (2020)
ACR Open Rheumatology
ACR Open Rheumatology
Objective This study aimed to evaluate the safety of avacopan, an orally administered C5a receptor inhibitor, for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in addition to standard-of-care (SOC) treatment with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9fed80daebe87ee4df42e0f5585432
https://doi.org/10.1002/acr2.11185
https://doi.org/10.1002/acr2.11185
Autor:
Annette Bruchfeld, Hasan Magin, Patrick Nachman, Samir Parikh, Richard Lafayette, Antonia Potarca, Shichang Miao, Pirow Bekker
Background Improvement of proteinuria as a marker for disease activity is associated with a better renal outcome in immunoglobulin A nephropathy (IgAN). Complement is an effector pathway in IgA-mediated kidney injury. Avacopan, a selective C5a recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b34dde9ad9db77f829c60c4c0f0bdc
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183928
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-183928
Autor:
John H. Stone, P. Jane McDowell, David R.W. Jayne, Peter A. Merkel, Joanna Robson, Naomi J. Patel, Yuqing Zhang, Huibin Yue, Pirow Bekker, Liam G. Heaney
Publikováno v:
Seminars in Arthritis and Rheumatism. 58:152124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eafb75c4278e8613d171638b2ee6615
https://doi.org/10.1016/j.semarthrit.2022.152124
https://doi.org/10.1016/j.semarthrit.2022.152124
Autor:
Pirow Bekker, Karen Ebsworth, Matthew J. Walters, Robert D. Berahovich, Linda S. Ertl, Trevor T. Charvat, Sreenivas Punna, Jay P. Powers, James J. Campbell, Timothy J. Sullivan, Juan C. Jaen, Thomas J. Schall
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine and the development of small-intestinal inflammation, the role of this chemokine-receptor p
Externí odkaz:
https://doaj.org/article/c638bdfdaf0d453fa06dafe9158d5f09
Autor:
John H. Stone, P. Jane McDowell, David R.W. Jayne, Peter A. Merkel, Joanna Robson, Naomi J. Patel, Yuqing Zhang, Huibin Yue, Pirow Bekker, Liam G. Heaney
Publikováno v:
Seminars in Arthritis and Rheumatism. 55:152010
Glucocorticoids (GCs) have been the cornerstone of treating dozens of inflammatory conditions for more than seven decades. GC toxicity is ubiquitous in both clinical trials and clinical practice, and toxicities associated with GC use are central to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f707d0f00f7cabc3bf5dfdd3af125f6
https://doi.org/10.1016/j.semarthrit.2022.152010
https://doi.org/10.1016/j.semarthrit.2022.152010