Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy.

Autor: Chen JH; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA. jhchen@broadinstitute.org.; Department of Pathology, MGH, Boston, MA, USA. jhchen@broadinstitute.org.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. jhchen@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. jhchen@broadinstitute.org., Nieman LT; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Spurrell M; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Department of Pathology, MGH, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Jorgji V; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Department of Pathology, MGH, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Elmelech L; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Department of Pathology, MGH, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Richieri P; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Xu KH; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Madhu R; Harvard Medical School, Boston, MA, USA.; Brigham and Women's Hospital, Division of Genetics, Boston, MA, USA., Parikh M; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Zamora I; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Mehta A; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Nabel CS; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA, USA., Freeman SS; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Pirl JD; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lu C; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Meador CB; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of Hematology/Oncology, MGH, HMS, Boston, MA, USA., Barth JL; Department of Pathology, MGH, Boston, MA, USA., Sakhi M; Center for Thoracic Cancers, MGH, Boston, MA, USA., Tang AL; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Sarkizova S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Price C; Vizgen, Cambridge, MA, USA., Fernandez NF; Vizgen, Cambridge, MA, USA., Emanuel G; Vizgen, Cambridge, MA, USA., He J; Vizgen, Cambridge, MA, USA., Van Raay K; NanoString Technologies, Seattle, WA, USA., Reeves JW; NanoString Technologies, Seattle, WA, USA., Yizhak K; Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Hofree M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Lautenberg Center for Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Shih A; Department of Pathology, MGH, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Sade-Feldman M; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Boland GM; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Surgery, MGH, Boston, MA, USA., Pelka K; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Gladstone-UCSF Institute of Genomic Immunology, Gladstone Institutes, San Francisco, CA, USA., Aryee MJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Mino-Kenudson M; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA.; Department of Pathology, MGH, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Gainor JF; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA. jgainor@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. jgainor@mgh.harvard.edu.; Center for Thoracic Cancers, MGH, Boston, MA, USA. jgainor@mgh.harvard.edu., Korsunsky I; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. ikorsunsky@bwh.harvard.edu.; Harvard Medical School, Boston, MA, USA. ikorsunsky@bwh.harvard.edu.; Brigham and Women's Hospital, Division of Genetics, Boston, MA, USA. ikorsunsky@bwh.harvard.edu., Hacohen N; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA. nhacohen@mgh.harvard.edu.; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA. nhacohen@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. nhacohen@mgh.harvard.edu.

Publikováno v: Nature immunology [Nat Immunol] 2024 Apr; Vol. 25 (4), pp. 644-658. Date of Electronic Publication: 2024 Mar 19.

Spatially organized multicellular immune hubs in human colorectal cancer.

Autor: Pelka K; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Hofree M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen JH; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA; Department of Pathology, MGH, Boston, MA, USA., Sarkizova S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Pirl JD; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Jorgji V; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA; Department of Pathology, MGH, Boston, MA, USA., Bejnood A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ge WH; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Xu KH; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Chao SX; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Department of Biomedical Informatics, HMS, Boston, MA, USA., Zollinger DR; NanoString Technologies Inc., Seattle, WA, USA., Lieb DJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Reeves JW; NanoString Technologies Inc., Seattle, WA, USA., Fuhrman CA; NanoString Technologies Inc., Seattle, WA, USA., Hoang ML; NanoString Technologies Inc., Seattle, WA, USA., Delorey T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Klapholz M; Evergrande Center for Immunologic Diseases, HMS and Brigham and Women's Hospital (BWH), Boston, MA, USA., Wakiro I; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Cohen O; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA; Department of Medical Oncology, DFCI, Boston, MA, USA., Albers J; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Smillie CS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu J; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Su MJ; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Yeung J; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Vijaykumar B; Department of Immunology, HMS, Boston, MA, USA., Magnuson AM; Department of Immunology, HMS, Boston, MA, USA., Asinovski N; Department of Immunology, HMS, Boston, MA, USA., Moll T; Clinical Research Center, MGH, Boston, MA, USA., Goder-Reiser MN; Clinical Research Center, MGH, Boston, MA, USA., Applebaum AS; Clinical Research Center, MGH, Boston, MA, USA., Brais LK; Clinical Research Center, DFCI, Boston, MA, USA., DelloStritto LK; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Denning SL; Clinical Research Center, DFCI, Boston, MA, USA., Phillips ST; Clinical Research Center, MGH, Boston, MA, USA., Hill EK; Clinical Research Center, DFCI, Boston, MA, USA., Meehan JK; Clinical Research Center, DFCI, Boston, MA, USA., Frederick DT; Clinical Research Center, MGH, Boston, MA, USA., Sharova T; Clinical Research Center, MGH, Boston, MA, USA., Kanodia A; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Todres EZ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA., Jané-Valbuena J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Biton M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Molecular Biology, MGH, Boston, MA, USA., Izar B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA; Department of Medical Oncology, DFCI, Boston, MA, USA., Lambden CD; Evergrande Center for Immunologic Diseases, HMS and Brigham and Women's Hospital (BWH), Boston, MA, USA., Clancy TE; Department of Surgery, BWH, Boston, MA, USA., Bleday R; Department of Surgery, BWH, Boston, MA, USA., Melnitchouk N; Department of Surgery, BWH, Boston, MA, USA., Irani J; Department of Surgery, BWH, Boston, MA, USA., Kunitake H; Department of Surgery, MGH, Boston, MA, USA., Berger DL; Department of Surgery, MGH, Boston, MA, USA., Srivastava A; Department of Pathology, BWH, Boston, MA, USA., Hornick JL; Department of Pathology, BWH, Boston, MA, USA., Ogino S; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Department of Pathology, BWH, Boston, MA, USA., Rotem A; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Vigneau S; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA., Johnson BE; Center for Cancer Genomics, Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA; Department of Medical Oncology, DFCI, Boston, MA, USA., Corcoran RB; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA; Department of Medicine, HMS, Boston, MA, USA., Sharpe AH; Evergrande Center for Immunologic Diseases, HMS and Brigham and Women's Hospital (BWH), Boston, MA, USA; Department of Immunology, Blavatnik Institute, HMS, Boston, MA, USA., Kuchroo VK; Evergrande Center for Immunologic Diseases, HMS and Brigham and Women's Hospital (BWH), Boston, MA, USA., Ng K; Department of Medical Oncology, DFCI, Boston, MA, USA., Giannakis M; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Department of Medical Oncology, DFCI, Boston, MA, USA., Nieman LT; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA., Boland GM; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA; Department of Surgery, MGH, Boston, MA, USA., Aguirre AJ; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Department of Medical Oncology, DFCI, Boston, MA, USA., Anderson AC; Evergrande Center for Immunologic Diseases, HMS and Brigham and Women's Hospital (BWH), Boston, MA, USA. Electronic address: acanderson@bwh.harvard.edu., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: orit@broadinstitute.org., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute and Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA, USA. Electronic address: aviv.regev.sc@gmail.com., Hacohen N; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA; Massachusetts General Hospital (MGH) Cancer Center, Harvard Medical School (HMS), Boston, MA, USA; Department of Immunology, HMS, Boston, MA, USA. Electronic address: nhacohen@mgh.harvard.edu.

Publikováno v: Cell [Cell] 2021 Sep 02; Vol. 184 (18), pp. 4734-4752.e20. Date of Electronic Publication: 2021 Aug 26.