Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Pirkko Viitala"'
Autor:
Mahmoud-Sobhy Elkhwanky, Valtteri Rinne, Pirkko Viitala, Kari T. Chambers, Mikko Karpale, Maija Mutikainen, Jukka Hakkola, Marcin Buler, Rudolf J. Wiesner, Brian N. Finck, Sanna-Mari Aatsinki, Pasi Tavi, Outi Kummu, Andras Franko
Publikováno v:
Diabetes
Low 25-hydroxyvitamin D levels correlate with the prevalence of diabetes; however, the mechanisms remain uncertain. Here, we show that nutritional deprivation–responsive mechanisms regulate vitamin D metabolism. Both fasting and diabetes suppressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e40bf2d2a1fe4f85857545d87610e3e
https://europepmc.org/articles/PMC6477896/
https://europepmc.org/articles/PMC6477896/
Publikováno v:
Biochemical Pharmacology. 63:429-435
Upregulation of mouse hepatic cytochrome P450 2A5 (CYP2A5) is a process closely associated with hepatocellular damage and formation of liver tumours. 2-Aminopurine, a protein kinase inhibitor modulating cell cycle control, was recently shown to stron
Autor:
Risto Kerkelä, Walter J. Koch, Johanna Magga, Raisa Serpi, Zoltan Szabo, Anne-Mari Moilanen, Pirkko Viitala, Ehre Gao, Anna-Maria Tolonen, Laura Vainio, Heikki Ruskoaho, Pauli Ohukainen
Publikováno v:
Pharmacology Research & Perspectives
The members of lethal-7 (Let-7) microRNA (miRNA) family are involved in regulation of cell differentiation and reprogramming of somatic cells into induced pluripotent stem cells. However, their function in the heart is not known. In this study, we ex
Autor:
Pirkko Viitala, Katja Posti, Sami Tetri, Susanna Leinonen, Hannu Raunio, Olavi Pelkonen, Sami Kottari
Publikováno v:
European Journal of Biochemistry. 264:19-26
Phenobarbital causes a multitude of effects in hepatocytes, including increased cell proliferation, inhibition of apoptosis and upregulation of xenobiotic and endobiotic metabolizing enzymes. In this study, the involvement of several protein kinase a
Autor:
Merja Korkalainen, Arja Rautio, Raimo Pohjanvirta, Nagabhooshan Hegde, Matti Viluksela, Heikki Henttonen, Olavi Pelkonen, Mari Murtomaa-Hautala, Otso Huitu, Pirkko Viitala
Publikováno v:
Environmental toxicology and chemistry. 31(3)
The gene expression and induction of cytochrome P450 (CYP)-enzymes following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) peroral administration was studied in the livers of two wild vole species—the bank vole (Myodes glareolus) and the field vole (M
Publikováno v:
Environmental toxicology and pharmacology. 29(1)
Previous studies in bank vole (Myodes glareolus) and field vole (Microtus agrestis) living at the old sawmill area contaminated by chlorinated dibenzo-p-dioxins and -furans (PCDD/Fs) showed that these two relatively close species have a significant d
Autor:
Paavo Honkakoski, Mika Reinisalo, Johanna Jyrkkärinne, Olavi Pelkonen, Hinfan Chung, Kaisa Niemi, Janne Mäkinen, Pirkko Viitala
mCAR (mouse constitutive androstane receptor; NR1I3) controls the expression of cytochrome P450 as well as other enzymes involved in drug and steroid metabolism. The high basal activity of mCAR can be modulated by inhibitory steroids related to andro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6ac4eb38749a87297b34ab8b33766
https://europepmc.org/articles/PMC1223782/
https://europepmc.org/articles/PMC1223782/
Autor:
Paavo Honkakoski, Janne Hukkanen, Olavi Pelkonen, Jukka Hakkola, Hannu Raunio, Pirkko Viitala
Publikováno v:
Pharmacokinetic Challenges in Drug Discovery ISBN: 9783662043851
Induction is defined as the increase in the amount and activity of a drug-metabolising enzyme, which is a long-term (hours and days) consequence of a chemical exposure. Previously, the study of induction of drug metabolism was largely empirical and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ecdd056faa33464bd53db5f09cfce6
https://doi.org/10.1007/978-3-662-04383-7_6
https://doi.org/10.1007/978-3-662-04383-7_6
Publikováno v:
Archives of toxicology. 72(6)
Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we ex