Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pirkko L Härkönen"'
Autor:
Kati M Tarkkonen, Emeli M Nilsson, Tiina E Kähkönen, Julien H Dey, Jari E Heikkilä, Johanna M Tuomela, Qing Liu, Nancy E Hynes, Pirkko L Härkönen
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49970 (2012)
Fibroblast growth factors (FGFs) regulate the growth and progression of breast cancer. FGF signaling is transduced through FGF receptors 1-4, which have oncogenic or anti-oncogenic roles depending on the ligand and the cellular context. Our aim was t
Externí odkaz:
https://doaj.org/article/f9b86713200448d0bd2888a412913140
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Supplementary Figure S2. The effect of adenosine on the kinetics of cell adhesion to extracellular matrix and MMP secretion by PC-3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aa7cd263f3b8b6f912d0be1f4118f0
https://doi.org/10.1158/1541-7786.22511589.v1
https://doi.org/10.1158/1541-7786.22511589.v1
Autor:
Gennady G. Yegutkin, Sirpa Jalkanen, Pirkko L. Härkönen, Kati Elima, Minna Vainio, Anu Kukkonen-Macchi, Sanna S. Virtanen
Extracellular adenosine mediates diverse anti-inflammatory, angiogenic, and other signaling effects via binding to adenosine receptors, and it also regulates cell proliferation and death via activation of the intrinsic signaling pathways. Given the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba785f63b08b3d5981c45ab01d650f48
https://doi.org/10.1158/1541-7786.c.6539982.v1
https://doi.org/10.1158/1541-7786.c.6539982.v1
Autor:
Tiina E. Kähkönen, Johanna M. Tuomela, Tove J. Grönroos, Jussi M. Halleen, Kaisa K. Ivaska, Pirkko L. Härkönen
Publikováno v:
Journal of Bone Oncology, Vol 16, Iss, Pp-(2019)
Advanced breast cancer has a high incidence of bone metastases. In bone, breast cancer cells induce osteolytic or mixed bone lesions by inducing an imbalance in bone formation and resorption. Activated fibroblast growth factor receptors (FGFRs) are i
Autor:
Mirkka J. Hirvonen, H. Kalervo Väänänen, Mika T. K. Mulari, Pirkko L. Härkönen, Kálmán G. Büki, Pirkko Vihko
Publikováno v:
Journal of Histochemistry & Cytochemistry. 6(7):537-549
Osteoclasts are bone-resorbing multinucleated cells that undergo drastic changes in their polarization due to heavy vesicular trafficking during the resorption cycle. These events require the precise orchestration of membrane traffic in order to main
Publikováno v:
Cancer research. 62(9)
Breast and prostate cancer preferentially metastasize in the skeleton, inducing locally increased bone resorption by osteoclasts. Bisphosphonates (BPs), potent inhibitors of osteoclasts and bone resorption, are able to reduce metastatic bone lesions,
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
Autor:
Mirjami M-T, Mattila, Johanna K, Ruohola, Terhi, Karpanen, David G, Jackson, Kari, Alitalo, Pirkko L, Härkönen
Publikováno v:
International journal of cancer. 98(6)
The spread of cancer cells to regional lymph nodes through the lymphatic system is the first step in the dissemination of breast cancer. In several human cancers including those of the breast and prostate, the expression of vascular endothelial growt
Autor:
Teresa D. Elo, Eeva M. Valve, Jani A. Seppänen, Heikki J. Vuorikoski, Sari I. Mäkelä, Matti Poutanen, Paula M. Kujala, Pirkko L. Härkönen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 11, Pp 915-927 (2010)
Expression of fibroblast growth factor 8 (FGF-8) is commonly increased in prostate cancer. Experimental studies have provided evidence that it plays a role in prostate tumorigenesis and tumor progression. To study how increased FGF-8 affects the pros
Externí odkaz:
https://doaj.org/article/667ddb3ad2e94540b9c2672821bbbc79