Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pirkko Kölle"'
Autor:
Pirkko Kölle, Alexander Seiler, Rolf D. Issels, Marcus Conrad, Hideyo Sato, Ana Banjac, Tamara Perisic, Peter T. Daniel, Norbert Weiss, Shiro Bannai, Georg W. Bornkamm, K Tschoep
Publikováno v:
Oncogene. 27:1618-1628
The glutathione-dependent system is one of the key systems regulating cellular redox balance, and thus cell fate. Cysteine, typically present in its oxidized form cystine in the extracellular space, is regarded as the rate-limiting substrate for glut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a5656955d7abec209ceb9438f72c45
https://doi.org/10.1038/sj.onc.1210796
https://doi.org/10.1038/sj.onc.1210796
Autor:
Julian Kirsch, Heike Beck, Manuela Schneider, Arne Östman, Theres Fey, Irina Ingold, Peter J. Kuhlencordt, Kristin Pogoda, Juliane Hellfritsch, Pirkko Kölle, Marcus Conrad, Markus Dagnell, Ulrich Pohl, José Pedro Friedmann Angeli, Irene Esposito, Markus Wortmann, Tamara Fluege, Jeroen Frijhoff
Publikováno v:
Antioxidants & Redox Signaling, 22(11), 938-950. Mary Ann Liebert Inc.
Aims: Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19413bdd144988a711e597ddc37afe7c
https://cris.maastrichtuniversity.nl/en/publications/9a773cd4-9ab4-44fd-ba88-7f2152d45391
https://cris.maastrichtuniversity.nl/en/publications/9a773cd4-9ab4-44fd-ba88-7f2152d45391
Autor:
Joachim Pircher, Peter J. Kuhlencordt, Juliane Hellfritsch, Markus Wortmann, Marcus Conrad, Naidu M. Vegi, Heike Beck, Georg W. Bornkamm, Michaela Aichler, Ulrich Pohl, Axel Walch, Pirkko Kölle, Manuela Schneider
Publikováno v:
Circ. Res. 113, 408-417 (2013)
Rationale: Growing evidence indicates that oxidative stress contributes markedly to endothelial dysfunction. The selenoenzyme glutathione peroxidase 4 (Gpx4) is an intracellular antioxidant enzyme important for the protection of membranes by its uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51375c4927c790c1a648c47a65eaa3b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=24921
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=24921
Autor:
Heidi Förster, Heike Beck, Peter J. Kuhlencordt, Pirkko Kölle, Marcus Conrad, Georg W. Bornkamm, Manuela Schneider, Pankaj Mandal
Publikováno v:
Cancer research 70(22), 9505-9514 (2010). doi:10.1158/0008-5472.CAN-10-1509
Tumor cells generate substantial amounts of reactive oxygen species (ROS), engendering the need to maintain high levels of antioxidants such as thioredoxin (Trx)- and glutathione (GSH)-dependent enzymes. Exacerbating oxidative stress by specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce22a3b467e11f7c2359d6cdb4e291c
https://pubmed.ncbi.nlm.nih.gov/21045148
https://pubmed.ncbi.nlm.nih.gov/21045148
Autor:
Alexander Seiler, Marcus Conrad, Elisabeth Kremmer, Tamara Perisic, Pankaj Mandal, Michael W. Lieberman, Ana Banjac Canak, Peter J. Kuhlencordt, Pirkko Kölle, Hideyo Sato, Shiro Bannai, Norbert Weiss, Heidi Förster, Georg W. Bornkamm
Publikováno v:
J. Biol. Chem. 285, 22244-22253 (2010)
GSH is the major antioxidant and detoxifier of xenobiotics in mammalian cells. A strong decrease of intracellular GSH has been frequently linked to pathological conditions like ischemia/reperfusion injury and degenerative diseases including diabetes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3d92d1a608916685c35d0c09b785f2
https://europepmc.org/articles/PMC2903358/
https://europepmc.org/articles/PMC2903358/
Autor:
Marcus Conrad, Hideyo Sato, Peter T. Daniel, Shiro Bannai, Georg W. Bornkamm, Norbert Weiss, Ana Banjac, Pirkko Kölle
Publikováno v:
GBM Annual Spring meeting Mosbach 2006. 2006
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14d7c29f90eb4a517592e5aa989d7968
https://doi.org/10.1240/sav_gbm_2006_m_001549
https://doi.org/10.1240/sav_gbm_2006_m_001549
Publikováno v:
Electrophoresis. 16:1927-1929
We report a new screening method for adenylosuccinate lyase (ASase) deficiency using capillary electrophoresis (CE). This enzyme defect causes secondary autism and psychomotor retardation in early childhood. In all body fluids of these patients, two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fd477eeaa45e3a1bdf9c9e2cee7daf
https://doi.org/10.1002/elps.11501601318
https://doi.org/10.1002/elps.11501601318