Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Pirkko J Pussinen"'
Autor:
Nele Fogelholm, Jaakko Leskelä, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkälä, Maria Eriksdotter, Kåre Buhlin, Pirkko J Pussinen, Päivi Mäntylä
Publikováno v:
Journal of Oral Microbiology, Vol 15, Iss 1 (2023)
ABSTRACTOral health and declining cognition may have a bi-directional association. We characterized the subgingival microbiota composition of subjects from normal cognition to severe cognitive decline in two cohorts.Memory and Periodontitis (MINOPAR)
Externí odkaz:
https://doaj.org/article/60429d98be85424a8d804916271e79f5
Autor:
Anne-Mari Määttä, Aino Salminen, Milla Pietiäinen, Jaakko Leskelä, Teemu Palviainen, Wolfgang Sattler, Juha Sinisalo, Veikko Salomaa, Jaakko Kaprio, Pirkko J Pussinen
Publikováno v:
Innate Immunity, Vol 27 (2021)
Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separa
Externí odkaz:
https://doaj.org/article/f8a9d04b0fab4988bc9057b7d8ba915f
Autor:
Jaakko Leskelä, Milla Pietiäinen, Anton Safer, Markku Lehto, Jari Metso, Ernst Malle, Florian Buggle, Heiko Becher, Jouko Sundvall, Armin J Grau, Pirkko J Pussinen, Frederick Palm
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228806 (2020)
INTRODUCTION:Periodontitis is associated with increased serum lipopolysaccharide (LPS) activity, which may be one mechanism linking periodontitis with the risk of cardiovascular diseases. As LPS-carrying proteins including lipoproteins modify LPS-act
Externí odkaz:
https://doaj.org/article/c3600a26f8124e4781f73a6d73152037
Autor:
Olavi Parkkonen, Mikko T Nieminen, Paula Vesterinen, Taina Tervahartiala, Markus Perola, Veikko Salomaa, Pekka Jousilahti, Timo Sorsa, Pirkko J Pussinen, Juha Sinisalo
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173371 (2017)
BACKGROUND:Matrix metalloproteinase 8 (MMP-8) is the most potent type-I collagen protease. Such collagen mainly constitutes the transient fibrosis in takotsubo cardiomyopathy (TTC) endomyocardial biopsies. High MMP-8 and tissue-inhibitor of matrix me
Externí odkaz:
https://doaj.org/article/237b088bcfe74fa0bf3e989daff8b047
Autor:
Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen, Nicolas Martinez-Majander, Eija Könönen, Teemu Niiranen, Leo Lahti, Juha Sinisalo, Jukka Putaala, Pirkko J. Pussinen, Susanna Paju
Publikováno v:
Journal of Oral Microbiology, Vol 16, Iss 1 (2024)
ABSTRACTBackground Gingivitis, i.e. inflammation of the gums, is often induced by dental plaque. However, its exact link to the oral microbiota remains unclear.Methods In a case-control study involving 120 participants, comprising 60 cases and 60 con
Externí odkaz:
https://doaj.org/article/d6ab7a99a1b840d1a5d5ad0508ae5d6c
Autor:
S Pauliina Turunen, Outi Kummu, Kirsi Harila, Marja Veneskoski, Rabah Soliymani, Marc Baumann, Pirkko J Pussinen, Sohvi Hörkkö
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34910 (2012)
OBJECTIVE:Increased risk for atherosclerosis is associated with infectious diseases including periodontitis. Natural IgM antibodies recognize pathogen-associated molecular patterns on bacteria, and oxidized lipid and protein epitopes on low-density l
Externí odkaz:
https://doaj.org/article/285e7a316d0a4bbc9156bc39f3187553
Autor:
Julia Ranta, Aki S. Havulinna, Taina Tervahartiala, Katriina Niemi, Ghazal Aarabi, Terhi Vihervaara, Veikko Salomaa, Timo Sorsa, Pirkko J. Pussinen, Aino Salminen
Publikováno v:
Frontiers in Dental Medicine, Vol 5 (2024)
BackgroundMatrix-degrading proteinases and their regulators, such as matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), may contribute to various pathological events. Elevated MMP-8 concentrations have bee
Externí odkaz:
https://doaj.org/article/5b8c1ccff8fe4741a09bee382e3dca50
Autor:
Aino Salminen, Milla Pietiäinen, Susanna Paju, Timo Sorsa, Päivi Mäntylä, Kåre Buhlin, Juha Sinisalo, Pirkko J. Pussinen
Background In our recent genome-wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP-8) concentration and the releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e99751540c71228a64f37efed7d18e
http://hdl.handle.net/10138/354201
http://hdl.handle.net/10138/354201
Autor:
Jacob Holmer, Maria Eriksdotter, Henrike Häbel, Ida Hed Myrberg, Anton Jonsson, Pirkko J. Pussinen, Sara Garcia‐Ptacek, Leif Jansson, Gunilla Sandborgh‐Englund, Kåre Buhlin
Background Periodontal disease has been proposed as a putative etiological factor for dementia. The aim of this investigation was to compare the incidence of dementia in individuals with or without deep probing pocket depths (DPPD), serving as a prox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c175fd6bd64e5daf7bf0920d40291c3
http://hdl.handle.net/10138/348361
http://hdl.handle.net/10138/348361
Autor:
María José Bordagaray, Claudia Vega, Alejandra Chaparro, Alejandra Fernández, Mauricio Garrido, Pirkko J. Pussinen, Anilei Hoare, Marcela Hernández, Constanza Jiménez
Publikováno v:
Clinical Oral Investigations. 26:993-1001
Porphyromonas (P.) species (spp.) are a major etiological agent of apical periodontitis (AP), which in turn represents a risk factor for cardiovascular diseases. This study explored the associations between endodontic infection with Porphyromonas spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16aad1fb2488b6173214984ffa2b4d6
https://doi.org/10.1007/s00784-021-04083-4
https://doi.org/10.1007/s00784-021-04083-4